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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 11 (1991), S. 299-306 
    ISSN: 0891-5849
    Keywords: 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl ; 5,5-Dimethyl-l-pyrroline N-oxide ; BCA ; Bicinchoninic ; DETAPAC ; DMPO ; Decrease in lipid peroxides ; Diethylenetriaminepentaacetic acid ; ESR ; Electron spin resonance ; Free radicals ; HPX ; Hypoxanthine ; Induction of SOD ; Low dose irradiation ; SOD ; Superoxide dismutase ; TBARS ; TEMPOL ; Thiobarbituric acid reacting substances ; XOD ; Xanthine-oxidase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 71 (1988), S. 165-175 
    ISSN: 1435-1463
    Keywords: Antidepressant ; adenylate cyclase ; GTP binding protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently, it has been suggested that antidepressant drugs exert their pharmacological action through functional changes in the adrenergic-receptor coupled adenylate cyclase system. In the present research, we examined the direct effects of antidepressants on adenylate cyclase (A-cyclase) activity by in vitro incubation of cell membranes from the cerebral cortex of rats with these drugs. All antidepressants examined, such as imipramine, clomipramine, amitriptyline, desipramine, mianserin and zimelidine inhibited A-cyclase in a dose dependent manner. Antidepressants did not exert any influence on Mn2+-induced elevation of A-cyclase, but significantly suppressed F−-stimulated A-cyclase activity. GTP-induced elevation of A-cyclase was completely inhibited by prior incubation with antidepressants. Our conclusion, therefore, is that antidepressants may reduce A-cyclase activity not by inhibiting the function of the catalytic unit of A-cyclase, but by supressing the N-protein function.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0827
    Keywords: 1,25-(OH)2-D ; Children ; Newborns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Plasma 1,25-dihydroxyvitamin D [1,25-(OH)2-D] was measured in cord serum, newborns, infants, and children. The mean for the values obtained from the six cords was significantly higher than the mean for the older children (6–15 years). The mean for the six newborns (0–1 week) was significantly higher than that for the older children. The mean for the nine infants (1 week-6 months) and the 14 younger children (6 months-6 years) was significantly higher than that for older children. The present study suggests that the perinatal period is associated with a marked increase in 1,25-(OH)2-D.
    Type of Medium: Electronic Resource
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