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  • 1-butene isomerization  (1)
  • Key words. Bone marrow stroma; negative growth regulator; antiproliferative effect; tumor growth; lung metastases.  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 55 (1999), S. 663-667 
    ISSN: 1420-9071
    Keywords: Key words. Bone marrow stroma; negative growth regulator; antiproliferative effect; tumor growth; lung metastases.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Bone marrow stroma produces positive and negative growth regulators which constitute the hematopoietic microenvironment. As many tumors metastasize to the bones, these regulators may also influence tumor growth. Hematopoietic cytokines may indeed exert both positive and negative effect on tumor growth. We report that, when mixed with tumor cells, adherent bone marrow cells inhibit primary tumor growth and metastases formation in mice transplanted with Lewis lung carcinoma or B16 melanoma. Peritoneal macrophages or lymph node cells did not exert any influence. The tumor inhibition was apparently due to soluble factor(s) released by marrow stromal cells. In cocultures with B16 melanoma cells, adherent bone marrow cells exerted a significant antiproliferative effect which was increased by previous culture of the bone marrow cells with granulocyte-macrophage colony-stimulating factor but not with macrophage colony-stimulating factor. Neither neutralizing antibodies against tumor necrosis factor-α, transforming growth factor-β or interferon α/β nor addition of Escherichia coli lipopolysaccharide to generate inflammatory cytokines could affect the antiproliferative effect of bone marrow stromal cells. The bone marrow stroma factor(s) which inhibit tumor growth might, therefore, be a novel growth regulator.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-8943
    Keywords: 1-butene isomerization ; M3+-substituted vanadyl phosphates ; structural characterization ; thermal characterization ; vanadyl phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A set of new materials with general formula [M(H2O)]X(VO)1−XPO4·2H2O (M 3+=Al, Cr, Ga, Mn), isomorphous with layered tetragonal VOPO4·2H2O and having potential catalytic properties, have been characterized by TG and DTA, X-ray diffraction and surface acid strength. During heating the compounds transform in the monohydrated and anhydrous phases, all maintaining a layered structure, with a proper interlayer spacing. Catalytic tests performed with 1-butene show that theM 3+-vanadyl phosphates greatly improve the conversion of the olefine with respect to pure vanadyl phosphate.
    Type of Medium: Electronic Resource
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