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  • 1
    Electronic Resource
    Electronic Resource
    High versus low-dose piracetam in alcohol organic mental disorder: a placebo controlled study (1990)
    Springer
    Psychopharmacology 100 (1990), S. 361-365 
    Details
    ISSN: 1432-2072
    Keywords: Piracetam ; Efficacy ; Dose ; Alcoholism ; Organic mental disorder ; Cognitive impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A marked tendency to increase the dose of piracetam in the treatment of organic mental disorder can be observed in clinical practice. A placebo controlled study comparing two doses (i.e. 6 g and 24 g per die) was performed to evaluate the benefits of high dose piracetam in the treatment of organic mental disorder of chronic alcohol addicts. 60 inpatients participated in the study. Cognitive impairment was verified by various psychological tests on day 0; patients were also evaluated on days 7, 14, 28 and 42 of the trial. While the patients of all three groups showed a significant amelioration during the treatment period, a modest but significant superiority was indicated for the high piracetam dose. There was no difference between the placebo group and the patients receiving low dose piracetam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244607
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol (1999)
    Springer
    Psychopharmacology 141 (1999), S. 175-181 
    Details
    ISSN: 1432-2072
    Keywords: Key words Olanzapine ; Dopamine D2 receptor ; 123I IBZM ; SPECT ; Atypical antipsychotic drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the degree of striatal dopamine-2 (D2) receptor occupancy in six schizophrenic patients receiving clinically effective antipsychotic treatment with olanzapine 10–25 mg/day in comparison to patients treated with clozapine 300–600 mg/day (n = 6) or haloperidol 5–20 mg/day (n = 10). 123I Iodobenzamide (IBZM) and single photon emission computerized tomography (SPECT) were used for the visualization of striatal D2 receptors. For the quantification of striatal D2 receptor occupancy, striatal IBZM binding in patients treated with antipsychotics was compared to that in untreated healthy controls (n = 8) reported earlier. Olanzapine led to a mean striatal D2 receptor occupancy rate of 75% (range 63–85). Haloperidol-treated patients showed dose-dependently (Pearson r = 0.64; P 〈 0.05) a significantly higher (P 〈 0.05) mean occupancy rate of 84% (range 67–94). During clozapine treatment, the mean D2 receptor occupancy of 33% (range 〈 20–49) was significantly lower than with olanzapine (P 〈 0.005). The higher striatal D2 receptor occupancy of haloperidol was correlated with the incidence and severity of extrapyramidal motor side-effects (EPS). No clinical relevant EPS occurred during treatment with olanzapine or clozapine. There was no correlation between the degree of striatal D2 receptor occupancy and clinical improvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050822
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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