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  • Analytical Chemistry and Spectroscopy  (8)
  • 13.10.+q  (4)
  • phase II  (4)
  • 1
    Digitale Medien
    Digitale Medien
    Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 205-209 
    Details
    ISSN: 1573-0646
    Schlagwort(e): phase II ; fazarabine ; adenocarcinoma ; pancreas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract We conducted a phase II evaluation of fazarabine 1.75–2.0 mg/m2hr over 72 hours every 28 days in 14 previously untreated patients with advanced adenocarcinoma of the pancreas. The intial dose was 1.75 mg/m2/hr in 10 patients, and 2.0 mg/m2hr in 4 patients. The dose was escalated in 8 patients, including all 4 who started at the higher dose level. Toxicity was unexpectedly mild. The median WBC nadir was 4.4 (range: 2.4–15.8)×103/μl, the median absolute neutrophil nadir was 3.2 (range: 0.9–13.0)×103/μl, and the median platelet count was 134.0 (range: 48.0–291.0)×103/μl. Gastrointestinal toxicity was generally mild. No major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00877247
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  • 2
    Digitale Medien
    Digitale Medien
    Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 313-316 
    Details
    ISSN: 1573-0646
    Schlagwort(e): phase II ; edatrexate ; adenocarcinoma ; pancreas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract We conducted a phase II evaluation of edatrexate in 17 previously untreated patients with advanced adenocarcinoma of the pancreas; 14 patients had at least one month of therapy. The initial dose was 80 mg/m2iv. Treatment was administered weekly for 5 weeks, then every other week. Toxicity was generally mild. The median WBC nadir was 5.4 (range 0.6–7.4)×103/μl, and the median platelet nadir was 164.0 (range 62.0–341.0)×103/μl. One patient died with sepsis and gastrointestinal bleeding associated with pancytopenia. Five patients had a mild rash. Nausea occurred in 6 patients, including 3 who had vomiting. In addition, 11 patients complained of vague malaise which seemed to begin within 24–48 hours after administration of edatrexate, and lasted for 2 to 3 days, resolving within 6 days of drug administration. Median survival was 85 days. Although 5 patients had stable disease, including one with relief of pain, no major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00944187
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  • 3
    Digitale Medien
    Digitale Medien
    Radiationless transition probabilities in muonic209Bi (1992)
    Springer
    The European physical journal 342 (1992), S. 245-246 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 13.10.+q ; 23.20.−g ; 36.10.−k ; 36.10.Dr
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The probability for non-radiative (n.r.) excitations in muonic209Bi was determined from a (μ −,γγ)-measurement by comparing the intensities of muonic X-ray transitions in single and coincidence spectra. The values of Pn.r(3p→1s)=(17.9±2.0)% and Pn.r.(3d→1s)=(3.0±2.2)% were measured for the first time. The strength of the n.r. decay of the 2p-level was found to be (4.2±2.2)%. The n.r. transition probabilities of two subcomplexes of the (2p→1s)-transition leading to different mean excitation energies are (3.2±1.8)% and (5.0±2.0)%, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01288477
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  • 4
    Digitale Medien
    Digitale Medien
    The study of prompt and delayed muon induced fission (1993)
    Springer
    The European physical journal 345 (1993), S. 89-95 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 13.10.+q ; 14.60.Ef ; 25.85.Ge ; 27.90.+b ; 36.10.Dr
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The ratios of prompt to delayed fission yields for the isotopes233U,234U,235U,236U,238U,237Np,242Pu, and244Pu and the fission probabilities relative to each other have been investigated experimentally. Using the value of the total fission probability for237Np the absolute probabilities for prompt and delayed fission have been determined. The fission probabilities per muon captureP fc have been derived for all the isotopes and compared with an evaluation based on excitation functions from theory.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01290344
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  • 5
    Digitale Medien
    Digitale Medien
    Nuclear excitation and prompt fission in muonic238U (1992)
    Springer
    The European physical journal 342 (1992), S. 111-120 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 13.10.+q ; 14.60.Ef ; 23.20.−g ; 25.30.−c ; 25.85.−w ; 27.90.+b ; 36.10.−k
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract A study of muonic238U has been performed in a combined (μ −,γ f) and (μ −,γγ) coincidence experiment to investigate the role of non-radiative transitions and their fission probabilities. An augmentation of the outer fission barrier ofΔE b =(0.6±0.1) MeV due to the presence of the muon is deduced. A significant contribution to the prompt fission yield not only results from the (2p→1s) and (3d→1s) non-radiative transitions, but also from other radiationless transitions. Specifically, the measured fission probabilities of the transitions (2p→1s), (3d→1s), and (3p→1s) are (1.5±0.4)%, (5.7±1.7)%, and (5.3±1.9)%, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01294496
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  • 6
    Digitale Medien
    Digitale Medien
    Delayed muon induced fission of209Bi and the role of meson-exchange currents (1992)
    Springer
    The European physical journal 343 (1992), S. 113-118 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 23.40.Bw ; 13.10.+q ; 25.85.−w ; 25.30.−c ; 27.80.+w ; 13.60.−r
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The probability for delayed muon induced fission of209Bi has been determined from a (μ −,f 1 f 2) measurement. The measured fission probability P f =(4.2±0.7)×10−5 is compared with theoretical predictions. The high fission threshold reaction seems well suited for studying the influence of two-body meson-exchange currents in nuclear muon capture.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01291603
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  • 7
    Digitale Medien
    Digitale Medien
    Phase II trial of gemcitabine (2,2′-difiuorodeoxycytidine) in patients with adenocarcinoma of the pancreas (1994)
    Springer
    Investigational new drugs 12 (1994), S. 29-34 
    Details
    ISSN: 1573-0646
    Schlagwort(e): pancreas ; adenocarcinoma ; gemcitabine ; 2,2′-difluorodeoxycytidme ; phase II
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Gemcitabine is a novel nucleoside analog which demonstrated a broad spectrum of preclinical acitivity in solid tumor models, and responses in patients with pancreas cancer during phase I evaluation. Patients with measurable adenocarcinoma of the pancreas who had received no previous chemotherapy were eligible for this multicenter phase II clinical trial. Gemcitabine 800 mg/m2 was administered intravenously weekly for 3 consecutive weeks, followed by one week rest, every 4 weeks. Forty-four patients entered the trial; 35 had at least 2 cycles of therapy. Partial response was observed in 5 patients (11%, estimated 95% confidence interval 2–20%), with a median duration of 13 months. All responding patients had stabilization or improvement in performance status. Fourteen patients had stable disease of 4 or more months. The median WBC nadir was 3.8 × 103/μl (range 1.6–9.3) and the median absolute neutrophil (ANC) nadir was 2.0 × 103/μl (range 0.4–7.2). Thrombocytopenia - 100.0 × 103/μl was observed in 15 patients; the median platelet nadir was 123.0 (range 30.0–245.0). All patients experienced a mild to moderate flu-like syndrome. In addition, one patient had a mild hemolytic-uremic syndrome which appeared related to gemcitabine therapy. Gemcitabine demonstrated marginal activity in this resistant neoplasm, without excessive toxicity. Further evaluation, including the use of more intense dosing and/or combination therapy, is warranted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00873232
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  • 8
    Digitale Medien
    Digitale Medien
    Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: unexpectant severe toxicity (1988)
    Springer
    Investigational new drugs 6 (1988), S. 239-241 
    Details
    ISSN: 1573-0646
    Schlagwort(e): ifosfamide ; phase II ; epidermoid carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Thirty-two patients with advanced epidermoid carcinoma of the esophagus were treated with ifosfamide (1.50 gm/m2 daily × 5 days) with uroprotective mesna in a phase II study. Eighteen patients were previously untreated. Of 28 evaluable patients, two (7%) had partial remissions lasting 2+ and 6+ months. Toxicity was predominantly myelosuppression with a median WBC nadir of 1.8 cells/ul. Seven patients required hospitalization for nadir sepsis. Ifosfamide has minimal activity in esophageal cancer and causes severe myelosuppression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00175406
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  • 9
    Digitale Medien
    Digitale Medien
    The mobile-phase effects on stationary-phase properties in capillary supercritical fluid chromatography (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 647-651 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Supercritical fluid chromatography (SFC) ; Stationary-phase phenomena ; Mobile-phase modifier ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A significant uptake of supercritical mobile phases into immobilized stationary phases has been observed. The phase swelling effect has been evaluated hydrodynamically for SE-30, SE-54, and cyanopropyl silicone phases with respect to the mobile-phase density of supercritical butane, column temperature, and the presence of a polar retention moderator. Some kinetic and retention consequences of the swelling phenomena are discussed.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240091111
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  • 10
    Digitale Medien
    Digitale Medien
    Investigation of retention and selectivity in high-temperature, high-pressure, open-tubular supercritical fluid chromatography with CO2 mobile phase (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 5 (1993), S. 441-449 
    Details
    ISSN: 1040-7685
    Schlagwort(e): open-tubular columns ; supercritical fluid chromatography ; retention ; selectivity ; pressure ; temperature ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: We studied solute retention for n-hydrocarbons, (low-molecular-weight) polystyrenes, an ethoxylated surfactant, and a selectivity test mix on open-tubular columns with methyl-, biphenyl-, and cyanopropyl-substituted stationary phases for pressures up to 680 atm and temperatures up to 240°C. The solute elution range varied tremendously with column choice, with the least retentive stationary phases providing the highest elution range. However, the best resolution and largest analysis range were obtained with the most retentive stationary phase and the highest pressures. Increasing the temperatures above 160°C did not cause a large increase in elution pressure for the solutes used in this study. Exceptionally large shifts in selectivity with temperatures up to about 160°C occurred for the biphenyl and cyanopropyl stationary phases. The availability of pressures higher than 680 atm, coupled with adequately retentive stationary phases used at optimal temperatures, would further increase the analysis scope of opentubular supercritical fluid chromatography.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mcs.1220050508
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