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  • 18F-fluoro-2′-deoxyuridine  (2)
  • subarachnoid hemorrhage  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgery today 3 (1973), S. 149-156 
    ISSN: 1436-2813
    Keywords: subarachnoid hemorrhage ; intracranial aneurysm ; early surgical treatment ; timing of surgery ; cerebral vasospasm ; consciousness of patient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been commonly accepted that the intracranial direct surgery, especially of aneurysmal neck occlusion, is the most desirable treatment for the intracranial aneurysm. However its timing is still controversial. In this report, early operation for the ruptured intracranial aneurysm was advocated based on the analysis of cases, encountered until the end of December, 1970, in which direct operation was performed within 3 weeks from the last subarachnoid hemorrhage, with special reference to the causes of death. The most reliable clinical parameter in deciding the timing of intracranial direct surgery seems to be the course of patient's consciousness. Age, blood pressure, site of aneurysm, motor disturbance, cranial nerve disorder and preoperative vasospasm were less related to the surgical results. The meningeal irritation and frequency of the past subarachnoid hemorrhage were related to the surgical results to some extent only. Therefore direct operation should be performed for the ruptured intracranial aneurysm even within one week after the last attack, providing the patient is neither in a state of coma nor in a down hill course of consciousness.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-2320
    Keywords: Aneurysm ; angioplasty ; balloon catheter, intravascular surgery ; subarachnoid hemorrhage ; vasospasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Of 455 cases of ruptured intracranial aneurysm treated with radical surgery from January 1987 to March 1992, 19 cases with high grade symptomatic vasospasm were treated by percutaneous transluminal balloon angioplasty (PTA). The indication for PTA was high grade symptomatic vasospasm which does not respond to conservative medical treatment. Of the 36 segments of vasospastic arteries, severe vasospams (angiographical constriction more than 50% of diameter on admission) was observed in 67%. PTA dialted these vasospastic arteries significantly (diameter of more than 75% of diameter on admission) in 83%. Follow up angiography revealed neither recurrence of vasospasm nor chronic atherosclerotic changes. Clinical improvement within 24 hours after PTA was observed in 63% of cases (7 of 17 cases with consciousness disturbance, 5 of 16 cases with motor weakness and one of 7 cases with aphasia). Outcomes at the time of discharge were excellent in 10 cases, good in 3, fair in 4, and lethal in 2. SPECT study before and after PTA confirmed improvement of cerebral blood flow in 3 out of 5 cases investigated. PTA for high grade symptomatic vasospasm after subarachnoid hemorrhage is considered an effective treatment method for the patient who does not respond to medical therapy. Immediate improvement of angiographical and clinical findings were frequently observed immediately after PTA. Exact indication and timing of PTA should be postulated after much more cases have been treated with this methal.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7373
    Keywords: 18F-fluoro-2′-deoxyuridine ; rat glioma ; PET ; bromodeoxyuridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To shed light on the metabolic changes in glioma following therapy, uptake changes among 18F-fluoro-2′-deoxyuridine (18FUdR), 14C-thymidine (dThd),14C-methionine (Met) and 3H-deoxyglucose (DG) in glioma model after chemotherapy were studied, as a means for interpreting clinical PET results, together with the changes in the bromodeoxyuridine (BUdR) labeling index. 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(-2 chloroethyl)-3-nitrosourea hydrochloride (ACNU) was administered intraperitoneally in the tumor-bearing rats and uptake of the tracers or BUdR labeling index in tumor tissue were measured. The metabolic response following chemotherapy was a sharp fall immediately for 14C-dThd and 18FUdR and a moderate fall for 14C-Met whereas there was a fall in 3H-DG from 1 week after chemotherapy. The changes of BUdR labeling index paralleled that in the uptake for dThd and FUdR. These result indicate that PET scans using a variety of tracers in conjunction could be used for clinical diagnosis and evaluation of therapy in glioma cases. 18FUdR is a promising tracer of nucleic acid metabolism to evaluate the proliferative potential of brain gliomas.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7373
    Keywords: 18F-fluoro-2′-deoxyuridine ; PET ; brain tumor ; glioma ; nucleic acid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p 〈 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.
    Type of Medium: Electronic Resource
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