ISSN:
0749-1581
Keywords:
3-Aryl-1-azabicyclo[2.2.2]octan-3-ols
;
2D NMR (COSY, NOESY and 1H—13C correlated spectroscopy)
;
1H—1H coupling constants in quinuclidine derivatives
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A series of (±)-3-aryl-1-azabicyclo[2.2.2]octan-3-ols were synthesized and studied by 1H, 13C and 2D NMR spectroscopy, and the crystal structure of (±)-3-(4-methylphenyl)-1-azabicyclo[2.2.2]octan-3-ol was determined by X-ray diffraction. The combined use of COSY, NOESY and 1H-13C correlation spectra of these compounds helped in the unambiguous and complete assignments of the bicyclic carbon and proton spin system. This study allows the establishment of the proton magnetic parameters for the quinuclidine moiety. Standard values of 1H—1H coupling constants are proposed in order to analyse more complex quinuclidine derivatives.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260291110
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