ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Influence of Helicobacter pylori infection and eradication on blood lipids and fibrinogen (2002)

Elizalde, J. I. ; Piqué, J. M. ; Moreno, V. ; [et al.]

Oxford UK : Blackwell Science Ltd.

Alimentary pharmacology & therapeutics 16 (2002), S. 0

add to mindlist on the mindlist

Details

ISSN: 1365-2036

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: An association between Helicobacter pylori infection and heart disease has been suggested. A potential mechanism may be inflammation-induced atherogenic changes of lipoproteins, but epidemiological studies have provided conflicting results.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:In a prospective multicentre study, 830 patients submitted for endoscopy and H. pylori testing were evaluated. Of the 686 H. pylori-positive patients, 487 received and 199 did not receive eradication treatment. Serum lipids and plasma fibrinogen were measured at baseline in all patients and 3 months later in those initially positive for H. pylori.〈section xml:id="abs1-3"〉〈title type="main"〉Results: H. pylori had no influence on baseline lipid or fibrinogen levels. Increases in high-density lipoprotein cholesterol were observed in 368 patients who received eradication treatment and in 193 untreated patients: 0.06 mmol/L (P=0.000) and 0.07 mmol/L (P=0.009), respectively. Similar minor increases in total cholesterol and triglycerides occurred in both groups. Lipid changes were related to symptom relief and a reduction in smoking. Eradication therapy was associated with a minor decrease in plasma fibrinogen irrespective of the resolution of infection.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions: H. pylori has no influence on blood lipids or fibrinogen. Both the eradication of infection and symptomatic treatment without eradication are associated with minor lipid changes related to symptom relief and lifestyle modifications. Thus, the inflammatory changes associated with H. pylori are unlikely to affect lipoprotein or fibrinogen metabolism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01202.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Structural characterization of (±)-3-aryl-1-azabicyclo[2.2.2]octan-3-ols by two-dimensional NMR spectroscopy and X-Ray crystallography. I (1991)

Arias-Pérez, M. S. ; Cosme, A. ; Gálvez, E. ; [et al.]

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 29 (1991), S. 1130-1139

add to mindlist on the mindlist

Details

ISSN: 0749-1581

Keywords: 3-Aryl-1-azabicyclo[2.2.2]octan-3-ols ; 2D NMR (COSY, NOESY and 1H—13C correlated spectroscopy) ; 1H—1H coupling constants in quinuclidine derivatives ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A series of (±)-3-aryl-1-azabicyclo[2.2.2]octan-3-ols were synthesized and studied by 1H, 13C and 2D NMR spectroscopy, and the crystal structure of (±)-3-(4-methylphenyl)-1-azabicyclo[2.2.2]octan-3-ol was determined by X-ray diffraction. The combined use of COSY, NOESY and 1H-13C correlation spectra of these compounds helped in the unambiguous and complete assignments of the bicyclic carbon and proton spin system. This study allows the establishment of the proton magnetic parameters for the quinuclidine moiety. Standard values of 1H—1H coupling constants are proposed in order to analyse more complex quinuclidine derivatives.

Additional Material: 5 Ill.