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  • Polymer and Materials Science  (8)
  • Cardiotoxicity  (2)
  • Gas chromatography  (2)
  • 1H magnetic resonance imaging  (1)
  • 1
    Electronic Resource
    Electronic Resource
    31P MR spectroscopy and 1H MR imaging of the human prostate using a transrectal probe (1991)
    Springer
    Urological research 19 (1991), S. 349-352 
    Details
    ISSN: 1434-0879
    Keywords: Human prostate ; 31P magnetic resonance Spectroscopy ; 1H magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1H magnetic resonance imaging and 31P nagnetic resonance spectroscopy of the human prostate using transrectal surface coild are discussed. 1H MR images were characterized by a high sensitivity, revealing many details in the prostate. Localized 31P spectra acquired during the same investigation showed phosphorous metabolites, which may help differentiate between benign prostatic hyperplasia and prostate carcinoma. An endoscopic transmit-receive radio frequency (RF) antenna is also described which can be used with very low RF power.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310148
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  • 2
    Electronic Resource
    Electronic Resource
    Calcium dynamics in cardiac myocytes as a target of dichloromethane cardiotoxicity (1996)
    Springer
    Archives of toxicology 70 (1996), S. 158-163 
    Details
    ISSN: 1432-0738
    Keywords: Key words Dichloromethane ; Cardiotoxicity ; [Ca2+]i transients ; Myocardial contraction ; Cardiac arrhythmia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The purpose of the present study was to determine if cardiac actions of dichloromethane (DCM) in vivo correlate with in vitro alterations of Ca2+ dynamics in cardiac myocytes. Neonatal rat ventricular myocytes were obtained from 2- to 4-day-old rats, and electrically induced fluctuations of cytosolic free Ca2+ concentration ([Ca2+]i) in single cardiomyocytes were investigated using spectrofluorometric analysis of fura-2-[Ca2+]i binding. In cultured myocytes, cumulative exposure to 0.64–40.96 mM DCM resulted in a concentration-dependent and reversible decrease in the magnitude of [Ca2+]i transients with IC10 and IC50 values of 7.98 and 18.82 mM, respectively. Total inhibition of [Ca2+]i transients and cessation of beating were observed at 40.96 mM DCM. Suffusion with DCM for 40 min did not cause morphological alterations of the myocytes. In a urethane-anesthetized rat model, left ventricular pressure was measured by introducing a tip catheter via the carotid artery into the left ventricle, the ECG was recorded by two needle electrodes applied subcutaneously to the chest wall, and arterial pressure was measured via the femoral artery. Oral administration of 3.1–12.4 mmol DCM/kg resulted in DCM blood concentrations between 1.0 and 1.6 mM, accompanied by a dose-dependent decrease in contractile force and heart rate without influencing blood pressure and ECG tracings. Moreover, DCM treatment provided significant protection against arrhythmia development due to CaCl2-infusion. In spite of the slight discrepancy between DCM blood concentrations and in vitro concentrations of DCM for [Ca2+]i transient inhibition, present data are consistent with the view that cardiac effects after DCM exposure are mediated by alterations of Ca2+ dynamics during excitation-contraction coupling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050255
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  • 3
    Electronic Resource
    Electronic Resource
    Cardiotoxicity of chlorodibromomethane and trichloromethane in rats and isolated rat cardiac myocytes (1997)
    Springer
    Archives of toxicology 71 (1997), S. 766-777 
    Details
    ISSN: 1432-0738
    Keywords: Key words Chlorodibromomethane ; Trichloromethane ; Cardiotoxicity ; [Ca2+] i transients ; Catecholamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg+0.31 mmol TCM/kg p.o.) in conscious and urethane anaesthetized male Wistar rats (n=610 per treatment). Furthermore it was observed whether cardiovascular responses were modified in CDBM or TCM treated rats after administration of exogenous catecholamines (epinephrine, 1 μg/kg; norepinephrine, 2 μg/kg) and underpinned with in vitro alterations of Ca2+ dynamics in cardiac myocytes. The present findings demonstrated that single and subacute oral administration of CDBM or TCM and mixtures of CDBM and TCM resulted in arrhythmogenic and negative chronotropic and dromotropic effects in conscious and urethane anaesthetized rats. The atrioventricular conduction time and the intraventricular extension time were extended. A slight shortening of the repolarization velocity was observed. The myocardial contractility was depressed and the heart was sensitized to the arrhythmogenic effects of epinephrine. After catecholamine injection the adrenergic cardiovascular responses in urethane anesthetized rats were modified: increased hypertensive epinephrine and norepinephrine action as well as augmentation of negative chronotropic and negative dromotropic cardiac effects of catecholamines were observed. The positive inotropic adrenergic response was diminished. The present in vivo findings, myocardial depression after acute CDBM treatment, as determined by different indices of contractility, correlate well with the observed inhibitory actions of CDBM on Ca2+ dynamics in isolated cardiac myocytes. All cardiovascular alterations found after CDBM or TCM treatment were not intensified after treatment with mixtures of CDBM and TCM. The effects observed were distinctly stronger after TCM (1.25 and 0.31 mmol/kg) treatment compared to CDBM (0.8 and 0.4 mmol/kg) treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050459
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  • 4
    Electronic Resource
    Electronic Resource
    Indirect GC determination of ethephon in drinking water by a combination of reactive headspace sampling with adsorptive enrichment/thermal desorption (1993)
    Springer
    Chromatographia 37 (1993), S. 361-364 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Headspace sampling ; PTV-System ; Ethephon in drinking water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary An indirect GC method is described for the determination of Ethephon in drinking water on the basis of the headspace analysis of the ethylene formed from Ethephon. In order to reach the necessary detection limit, the entire volume of the static headspace distribution is transferred into a cold injection system (CIS). There, the ethylene is adsorbed on Carbosieve SIII at 10°C and, subsequently, desorbed at 300 °C. The water vapour included in the headspace is completely eliminated through the splitting system. By means of this technique, a detection limit of 0.05 μg/l water was reached.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272249
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  • 5
    Electronic Resource
    Electronic Resource
    Radiolysis of polymers of chlorine methacrylates (1988)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 26 (1988), S. 2669-2681 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Polymers of α-chloroacrylate (MCA), 1-chloroethyl methacrylate (1CEMA), 2-chloroethyl methacrylate (2CEMA), 2,2,2-trichloroethyl methacrylate (trCEMA) and 1,2,2,2-tetrachloroethyl methacrylate (teCEMA) were γ-irradiated at 77 K. The primary radicals were generated by the abstraction of chlorine. They decay or change into chain end radicals upon warming up to room temperature.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1988.080261004
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  • 6
    Electronic Resource
    Electronic Resource
    Radiation induced radical reactions in poly(chloroalkyl methacrylate)s/triallylisocyanurate mixtures (1989)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 1589-1598 
    Details
    ISSN: 0887-624X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Radical generation after γ-irradiation at 77 K and radical reactions during temperature increase are discussed for the polymers poly(2-chloroethyl methacrylate) and poly(1,2,2,2-tetrachloroethyl methacrylate), mixed with triallylisocyanurate (TAIC). After the radiation interaction radicals are generated in the ester alkyl side groups of the polymer by chlorine abstraction in both polymer/TAIC mixtures. Radical transfer to TAIC occurs during temperature increase to produce allyl radicals. Hence, the high radiation sensitivity of chlorine-containing polymers is combined with the reactivity of allyl radicals of TAIC in such polymer-TAIC mixtures.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1989.080270510
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  • 7
    Electronic Resource
    Electronic Resource
    Gas chromatographic water analysis by direct injection of large sample volumes in an adsorbent-packed PTV injector (1994)
    Springer
    Chromatographia 38 (1994), S. 694-700 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; PTV injection system ; Aqueous samples ; Pesticides ; Breakthrough volumes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A GC method is described for the determination of pollutants in aqueous samples by direct enrichment out of large sample volumes in a PTV injector. The vaporized water is eliminated through the split vent and the analytes are concentrated on an adsorbent inside the insert of the PTV. For the selection of suitable adsorbents, breakthrough volumes of selected pesticides and nitroaromatics on Tenax TA, Tenax GR, Chemipack C18 and graphitized carbon blacks have been determined by experiment. The determination of the breakthrough volumes was carried out directly in the PTV insert. Tenax TA proved to be the best sorbent with regard to the breakthrough volumes and its inertness to the analytes to be determined. As the result of the investigations, 500 μl of aqueous standard solutions of pesticides and nitroaromatics (concn.=0.02 ... 2 μg/l) were analyzed with an average relative standard deviation of 10%. The procedure was successfully applied for the analysis of real samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269623
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  • 8
    Electronic Resource
    Electronic Resource
    EPR-Untersuchungen γ-bestrahlter chlorsubstituierter Poly(methacrylate) (1987)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 114-119 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: γ-radiolysis of poly(methyl methacrylate) (PMMA) and chlorosubstituted poly(methacrylates) gives radicals with comparable nine-line-EPR spectra. The transformations of the molecules were discussed in light of the quantitative differences in the accumulation processes. EPR-spectra at liquid helium temperatures confirm the hypothesis of allyl radical accumulation in PMMA.
    Notes: Die im Poly(methylmethacrylat) (PMMA) und in chlorsubstituierten Poly(methacrylaten) radiolytisch erzeugten Radikale ergeben ähnliche EPR-Neunlinienspektren. Molekülumwandlungen zur Deutung der quantitativ unterschiedlichen Akkumulationsprozesse werden diskutiert. EPR-Spektren bei Heliumtemperaturen bestätigen die Hypothese der Akkumulation von Allylradikalen im PMMA.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1987.010380204
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  • 9
    Electronic Resource
    Electronic Resource
    Morphologische Besonderheiten polymerer Mehrkomponentensysteme auf der Basis von Dithiolen und Diisocyanaten (1979)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 30 (1979), S. 496-502 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Polyurethanes obtained by reacting mercapto-terminated oligobutadienes, decanedithiol and diisocyanate were investigated by electron microscopy and x-ray scattering. The dependence of the morphological structure on the content of short-chain dithiol is discussed. Heterogeneities in micro- and macroregions were observed, which are caused by crystalline regions and phase separation in chemically different blocks.
    Notes: Polyurethane auf der Basis von mercapto-terminierten Oligobutadienen, Decandithiol und Diisocyanat werden mittels Elektronenmikroskopie und Röntgenstreuung untersucht. Ihre morphologischen Besonderheiten werden in Abhängigkeit vom Gehalt an Kurzkettendithiol diskutiert. Es treten Heterogenitäten im Mikro- und Makrobereich auf, die durch kristalline Bereiche und Phasentrennung in chemisch unterschiedliche Blöcke bedingt sind.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1979.010300807
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of ion beam damage effects in poly(1,2,2,2-tetrachloroethyl methacrylate) by ESCA (1987)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 38 (1987), S. 638-639 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1987.010381111
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