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  • lipid peroxidation  (2)
  • 2-hydroxytetrahydrofuran  (1)
  • Ethidium  (1)
  • Micropuncture  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of certain diuretics on the electrophysiological characteristics of the nephron in the rat kidney (1975)
    Springer
    Pflügers Archiv 360 (1975), S. 81-89 
    Details
    ISSN: 1432-2013
    Keywords: Micropuncture ; Active Transport ; Sodium Transport ; Potassium Transport ; Diuretics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electrophysiological micropuncture techniques were used to study the effect of certain diuretics on transtubular transport of electrolytes in the rat kidney. The mercurial diuretic novurite caused a reduction of active sodium transport in the proximal tubule, measured by short-circuit current and increased permeability of the tubular wall to ions which led to a considerable drop in transtubular potential and transepithelial resistance. Ethacrynic acid decreased the shortcircuit current in the proximal tubule, without changing the permeability characteristics of the nephron. Xanthine diuretic euphylline did not reduced the short-circuit current in the proximal segment of the nephron; however, it increased the transepithelial potential of the renal tubule. In the distal tubule, euphylline and ethacrynic acid increased the difference in transtubular potential, whereas novurite distal tubule as a result of euphylline and ethacrynic acid action may be responsible for increasing potassium excretion. A decrease of the transtubular potential in the distal tubule under the action of novurite may serve to explain a lack of significant potassium excretion under mercurial diuretic action. The reduction of tubular reabsorption as a result of diuretic action is due to drug effect on different levels of the transtubular-ion transport system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584328
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tautomerism and vapor-phase transformations of 2-hydroxytetrahydrofuran (2000)
    Springer
    Chemistry of heterocyclic compounds 36 (2000), S. 775-778 
    Details
    ISSN: 1573-8353
    Keywords: 2-hydroxytetrahydrofuran ; 4-hydroxybutanal ; 2,3-dihydrofuran ; tautomerism ; dehydration ; AM1 method ; concerted mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The relative stability of 2-hydroxytetrahydrofuran and the tautomeric 4-hydroxybutanal was determined by the semi-empirical AM1 method. It was concluded that the cyclic tautomer predominates in the gas phase at 25°C. Vapor-phase dehydration of 2-hydroxytetrahydrofuran in the presence of porcelain and silica gel L leads to a quantitative yield of 2,3-dihydrofuran.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02256908
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of diuretics on the intensity of lipid peroxidation and antioxidant protection of blood plasma (1994)
    Springer
    Bulletin of experimental biology and medicine 117 (1994), S. 474-475 
    Details
    ISSN: 1573-8221
    Keywords: lipid peroxidation ; diene conjugates ; malonic dialdehyde ; antioxidant activity ; vitamin E
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An increase in the content of primary and final lipid peroxidation (LPO) products and a decrease in the fat- and water-soluble antioxidants in blood plasma are revealed in a study of hypohydration induced by administration of 40 mg furosemide alone or in combination with 1 tablet of triampure. Intensification of free radical processes in states simulating weightlessness may be related to the loss of fluid due to transformation of water-electrolyte metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02444291
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of age and ischemia on levels of lipoperoxides and lipid-soluble antioxidants in the human heart (1995)
    Springer
    Bulletin of experimental biology and medicine 119 (1995), S. 561-563 
    Details
    ISSN: 1573-8221
    Keywords: human heart ; age ; ischemia ; lipid peroxidation ; antiradical activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Levels of lipoperoxides and hydrophobic scavengers of free radicals were estimated in n-hexane extracts of myocardial biopsy specimens taken from cardiac patients (children and adults) during surgical operations. Ultraviolet spectra of these extracts were found to contain four absorption bands with peaks at 214, 233, 258, and 298 nm that characterize the levels of diene and triene conjugates. A comparison of the data obtained for children and adults suggested that the total antiradical activity of the cardiac muscle decreases while its content of vitamin E remains virtually unchanged during ontogeny. Significantly reduced vitamin E levels were noted in specimens from patients with chronic ischemic heart disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02443689
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  • 5
    Electronic Resource
    Electronic Resource
    Ethidium and azidoethidium oligonucleotide derivatives: Synthesis, complementary complex formation and sequence-specific photomodification of the single-stranded and double-stranded target oligo- and polynucleotides (1994)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 7 (1994), S. 177-188 
    Details
    ISSN: 0952-3499
    Keywords: Sequence-specific photomodification ; Oligonucleotide derivatives ; Ethidium ; Azidoethidium ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Oligodeoxyribonucleotide derivatives containing ethidium or azidoethidium residues attached to 3′ and/or 5′ end were prepared. These derivatives formed tight specific complexes with complementary oligodeoxyribonucleotides where each attached ethidium residue led to an increase of complex Tm by 20-30°C. Tandem complexes of two oligodeoxyribonucleotides containing ethidium residues with an oligodeoxyribonucleotide having two adjacent complementary sequences for these Oligonucleotide were investigated. Photoinduced reactions of a number of ethidium and azidoethidium oligodeoxyribonucleotide derivatives with target complementary single-stranded and double-stranded oligo- and polydeoxyribonucleotides were investigated. The irradiation led to direct photocleavage of the target oligo- or polynucleotide, to formation of hidden (piperidine cleavable) modifications of the target of formation of covalent adducts between ethidium oligodeoxyribonucleotide derivative and the target. In a number of experiments, azidoethidium dyes were demonstrated to be considerably stronger photosensitizers than ethidium ones. Depending on the nature of the target (single- or double-stranded DNA) and on the irradiation conditions, the total damages to the target oligo- or polydeoxyribonucleotides ranged from 10-70% (for ethidium dyes) to 30-80% (for azidoethidium dyes).
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmr.300070305
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    Paper (German National Licenses)
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