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  • 2-naphthol sulphotransferase  (1)
  • Tail tendon  (1)
  • cytosolic calcium  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacodynamics of salmon calcitonin in humans: New markers of pharmacological activity (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 229-233 
    Details
    ISSN: 1432-1041
    Keywords: Salmon calcitonin ; pharmacodynamics ; adenosine ; pO2 IM dosing ; nasal spray dosing ; cytosolic calcium ; neutrophils ; platelets ; lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to define the pharmacodynamic profile of salmon calcitonin (sCT) in humans, several markers of the biological activity of the drug have been studied, namely cAMP, adenosine and pO2 in venous blood, and the cytosolic free calcium level in circulating cells. Different dosages and routes of administration (1.5 IU. kg−1 and 0.75 IU kg−1 IM, and 1.5 IU. kg−1 via nasal spray) were compared. sCT caused an increase in cAMP, adenosine and pO2, and a decrease in cytosolic free calcium in neutrophils, lymphocytes and platelets. The peak times of all these parameters ranged between 109 and 182 min, and 101 and 168 min after IM and nasal spray administration respectively. There was greater variability in the values after IM than nasal spray of administration of sCT. It is concluded that adenosine and p02 in venous blood, and cytosolic free calcium in circulating cells are valuable markers of the activity of sCT and that sCT decreases the cytosolic free calcium level in neutrophils, lymphocytes and platelets. Pharmacodynamic analysis of the biological effects of the drug is highly reliable and valuable in predicting its pharmacological profile. sCT administration via a nasal spray is able to produce significant biological effects, although they are less marked than after IM dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333015
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of 2-naphthol sulphotransferase and its endogenous substrate adenosine 3′-phosphate 5′-phosphosulphate in human tissues (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 317-320 
    Details
    ISSN: 1432-1041
    Keywords: 2-naphthol sulphotransferase ; adenosine 3′-phosphate 5′-phosphosulfate ; liver ; kidney ; lung ; intestine ; tissue distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The activity of sulphotransferase towards 2-naphthol and the concentration of its endogenous substrate, adenosine 3′-phosphate 5′-phosphosulphate (PAPS), have been measured in five specimens of human liver, lung, and kidney, and the mucosa from the ileum and the ascending, descending and sigmoid colon. The activity of 2-naphthol sulphotransferase (mean nmol·min−1·mg−1 protein) was 1.82 (liver); 0.034 (kidney); 0.19 (lung); 0.64 (ileum); 0.47 (ascending colon); 0.50 (descending colon); 0.40 (sigmoid colon). The concentration of PAPS (mean nmol·g−1 wet tissue) was 22.6 (liver); 4.8 (kidney); 4.3 (lung); 12.8 (ileum); 8.1 (ascending colon); 7.5 (descending colon); 6.2 (sigmoid colon). The concentration of PAPS and the activity of 2-naphthol sulphotransferase were higher in the liver than in the extrahepatic tissues. There was significant difference between ileum and ascending colon, both the activity of sulphotransferase and the concentration of PAPS being higher in the former. 2-Naphthol sulphotransferase activity and the concentration of PAPS have consistent distribution patterns. Differences between the tissues studied were more marked for sulphotransferase than for its endogenous substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679793
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Arrangement of microfibrils in collagen fibrils of tendons in the rat tail (1983)
    Springer
    Cell & tissue research 234 (1983), S. 735-743 
    Details
    ISSN: 1432-0878
    Keywords: Collagen microfibrillar arrangement ; Freeze-fracture ; Tail tendon ; X-ray diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The microfibrillar arrangement in collagen fibrils of tendons in the tail of the rat was examined by electron microscopy and X-ray diffraction. Fresh and air-dried collagen fibers were examined in unstretched and stretched conditions. The results demonstrate that the microfibrils have a course parallel to the longitudinal axis of the collagen fibrils. The influence of stretching and hydration of the samples on the orientation of fibrils and microfibrils is also assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218664
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    Paper (German National Licenses)
    Fulltext
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