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  • 1
    Electronic Resource
    Electronic Resource
    Distribution of 2-naphthol sulphotransferase and its endogenous substrate adenosine 3′-phosphate 5′-phosphosulphate in human tissues (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 317-320 
    Details
    ISSN: 1432-1041
    Keywords: 2-naphthol sulphotransferase ; adenosine 3′-phosphate 5′-phosphosulfate ; liver ; kidney ; lung ; intestine ; tissue distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The activity of sulphotransferase towards 2-naphthol and the concentration of its endogenous substrate, adenosine 3′-phosphate 5′-phosphosulphate (PAPS), have been measured in five specimens of human liver, lung, and kidney, and the mucosa from the ileum and the ascending, descending and sigmoid colon. The activity of 2-naphthol sulphotransferase (mean nmol·min−1·mg−1 protein) was 1.82 (liver); 0.034 (kidney); 0.19 (lung); 0.64 (ileum); 0.47 (ascending colon); 0.50 (descending colon); 0.40 (sigmoid colon). The concentration of PAPS (mean nmol·g−1 wet tissue) was 22.6 (liver); 4.8 (kidney); 4.3 (lung); 12.8 (ileum); 8.1 (ascending colon); 7.5 (descending colon); 6.2 (sigmoid colon). The concentration of PAPS and the activity of 2-naphthol sulphotransferase were higher in the liver than in the extrahepatic tissues. There was significant difference between ileum and ascending colon, both the activity of sulphotransferase and the concentration of PAPS being higher in the former. 2-Naphthol sulphotransferase activity and the concentration of PAPS have consistent distribution patterns. Differences between the tissues studied were more marked for sulphotransferase than for its endogenous substrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679793
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  • 2
    Electronic Resource
    Electronic Resource
    New in vivo model to assess venous endothelial cell functions. Effect of defibrotide (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 351-357 
    Details
    ISSN: 1432-1041
    Keywords: defibrotide ; fibrinolysis ; endothelial cells ; tissue plasminogen activator (tPA) ; plassminogen activator inhibitor (PAI)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract In the past few years there has been increasing interest in the role of the vascular endothelium as an active modulator of biological responses. Endothelial cells exert antithrombotic activity by the release of prostacyclin [23] and adenine nucleotides [16], the availability on the cell surface of heparin-like substances [3], and thrombomodulin-mediated activation of protein C [8]. In addition, endothelium is involved in the regulation of fibrinolysis by releasing soluble factors, such as tissue plasminogen activator (tPA; [10]) and plasminogen activator inhibitor (PAI; [22, 11]), as well as in the control of vascular responsiveness by the production of smooth muscle relaxing and contracting factors. Endothelial cells have also been shown to synthesize and to express procoagulant activities [18]. Many data on endothelial cell functions has been obtained from two experimental models, namely endothelial cell cultures and perfused segments of animal and human vessels. Both are subject to methodological criticism since they only represent in part in vivo conditions, and the necessary experimental manipulations and laboratory procedures greatly modify the naturally occurring cellular functions. In order to overcome such difficulties as far as possible, a new in vivo model has been employed to provide easily assessable and reliable data on the properties of endothelial cells in man. A venous segment was isolated functionally by cannulating a dorsal vein in the hand and a cubital vein in the same arm. Changes observed ex vivo in blood from the cubital vein following infusion into the hand vein of an active drug, can mainly be attributed to its local effect on the venous wall. At the same time, a cubital vein in the other arm was cannulated in order to provide information to distinguish systemic from regional effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558499
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacodynamics of salmon calcitonin in humans: New markers of pharmacological activity (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 229-233 
    Details
    ISSN: 1432-1041
    Keywords: Salmon calcitonin ; pharmacodynamics ; adenosine ; pO2 IM dosing ; nasal spray dosing ; cytosolic calcium ; neutrophils ; platelets ; lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In order to define the pharmacodynamic profile of salmon calcitonin (sCT) in humans, several markers of the biological activity of the drug have been studied, namely cAMP, adenosine and pO2 in venous blood, and the cytosolic free calcium level in circulating cells. Different dosages and routes of administration (1.5 IU. kg−1 and 0.75 IU kg−1 IM, and 1.5 IU. kg−1 via nasal spray) were compared. sCT caused an increase in cAMP, adenosine and pO2, and a decrease in cytosolic free calcium in neutrophils, lymphocytes and platelets. The peak times of all these parameters ranged between 109 and 182 min, and 101 and 168 min after IM and nasal spray administration respectively. There was greater variability in the values after IM than nasal spray of administration of sCT. It is concluded that adenosine and p02 in venous blood, and cytosolic free calcium in circulating cells are valuable markers of the activity of sCT and that sCT decreases the cytosolic free calcium level in neutrophils, lymphocytes and platelets. Pharmacodynamic analysis of the biological effects of the drug is highly reliable and valuable in predicting its pharmacological profile. sCT administration via a nasal spray is able to produce significant biological effects, although they are less marked than after IM dosing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333015
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  • 4
    Electronic Resource
    Electronic Resource
    Toothbrush filaments end-rounding: stereomicroscope analysis (2001)
    Copenhagen : Munksgaard International Publishers
    Journal of clinical periodontology 28 (2001), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Background, aims: Toothbrush filaments with rounded ends allow for efficient removal of bacterial plaque and are less harmful to periodontal tissues than non-rounded bristles. The aim of this research was to evaluate the % of rounded filaments considered to be of acceptable quality in different toothbrush brands and to determine whether there is a standardization of quality, as manufacturers claim.Method: Brushes tested included 2 samples of medium-hard nylon or tynex toothbrushes from 31 various types found on the retail market in Italy. Tufts from the same position on the toothbrush head were removed and examined under a stereomicroscope, utilizing methods which did not alter the physical properties of the filaments. In 4 of the 31 toothbrush brands tested, more than 50% of the filaments appeared rounded, in 19 of them, between 11.9% and 40.5% and in 8 brands between 0% and 7%.Results: Differences were found in the number and disposition of filaments among different brands and even within the same toothbrush brand.Conclusion: The results appear to indicate that a large % of toothbrushes on the retail market do not meet acceptable quality criteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-051x.2001.028004360.x
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  • 5
    Electronic Resource
    Electronic Resource
    Severe factor X deficiency in pregnancy: case report and review of the literature (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  Isolate factor X deficiency is an extremely rare clotting factor disorder inherited in autosomal recessive fashion and pregnancy in a homozygous patient is frequently complicated by recurrent miscarriage, uterine bleeding and premature labour. Eleven pregnancies in seven patients affected by FX deficiency have been reported in the literature. Two additional pregnancies have been reported in a FX variant (FX Friuli). We present a new case of successful at term pregnancy in a homozygous patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.01012.x
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  • 6
    Electronic Resource
    Electronic Resource
    Digital imaging with a pressured xenon filled MWPC working at a high data rate
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 228 (1984), S. 193-200 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(84)90031-7
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  • 7
    Electronic Resource
    Electronic Resource
    Supracrestal circular collagen fiber network around osseointegrated nonsubmerged titanium implants (1992)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 3 (1992), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eight non-submerged titanium implant screws were placed in the first upper molar edentulous sites of monkeys and subsequently kept loaded with single crown prosthesis 1 month following implantation. The animals were killed after a further 14 months and specimens including implant and adjacent teeth were processed for light and electron microscopy. Histological pictures of all samples showed the neck and most of the screw body to be surrounded by new bone. The soft tissue surrounding the implant post included pocket epithelium and supra-crestal connective tissue displaying collagen fiber bundles comparable to gingival ligaments. These peri-implant collagen fiber bundles arose from the neighboring alveolar crest, root cementum of adjacent teeth or, superficially, from the epithelium and followed a circular array around the implant neck.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1992.030403.x
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  • 8
    Electronic Resource
    Electronic Resource
    Role of Peri-Implant Medullary Cisternae in the Osseo-Integration of Smooth Surface Endosseous Dental Implants (2000)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 192-195 (Sept. 2000), p. 429-432 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/45/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.192-195.429.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Studies on the adsorption and binding of nucleic acids on clay minerals (1996)
    Springer
    Origins of life and evolution of the biospheres 26 (1996), S. 254-255 
    Details
    ISSN: 1573-0875
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02459742
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  • 10
    Electronic Resource
    Electronic Resource
    Arrangement of microfibrils in collagen fibrils of tendons in the rat tail (1983)
    Springer
    Cell & tissue research 234 (1983), S. 735-743 
    Details
    ISSN: 1432-0878
    Keywords: Collagen microfibrillar arrangement ; Freeze-fracture ; Tail tendon ; X-ray diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The microfibrillar arrangement in collagen fibrils of tendons in the tail of the rat was examined by electron microscopy and X-ray diffraction. Fresh and air-dried collagen fibers were examined in unstretched and stretched conditions. The results demonstrate that the microfibrils have a course parallel to the longitudinal axis of the collagen fibrils. The influence of stretching and hydration of the samples on the orientation of fibrils and microfibrils is also assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218664
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