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  • Bladder cancer  (2)
  • decentralized state feedback controllers  (2)
  • 21.30.+Y  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 332 (1989), S. 1-7 
    ISSN: 1434-601X
    Keywords: 21.10.Dr ; 21.30.+Y ; 21.60.Cs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The results of a calculation in the generalized seniority scheme for the odd-oddN=83 isotones is presented. Results are compared with data and with a calculation in the framework of the IBA model. From the latter estimates for parameters in the bosonfermion interaction have been obtained.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Key words p53 codon 72 polymorphism ; Bladder cancer ; Proline form ; Arginine form
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abnormal function of p53 is commonly associated with various cancer formations. High-grade and late-stage bladder cancers have been reported to have mutated or become inactive p53 when using immunohistochemical stains. Recently, p53 codon 72 polymorphism was extensively studied to determine the risk factors responsible for cancer formation. There was a general population of codon 72 sequence polymorphism of the wild type p53. A single base change from G to C caused the alteration of amino acid residue 72 from arginine to proline. The arginine form is considered to be a significant risk factor in the development of cancer. However, various reports had indicated discrepancies with regard to this polymorphism; some showed no significant difference between the control and cancer groups, while other series were associated with high risks in the proline form homozygotes. To resolve the undefined distribution of this polymorphism in bladder cancers, 58 patients with bladder cancer were enrolled onto this study. When checked using the Chi-squared test (P=0.952) there were no differences between the control subjects and bladder cancer patients in the distribution of polymorphism. However, proline form homozygotes were more frequently found in the invasive group than the non-invasive group by Fisher's exact test (25% and 2.9%, respectively, P 〈 0.001). More than 70% of the non-invasive bladder cancers were the arginine form homozygotes. This result is consistent with those reported for hepatocellular carcinoma that showed a history of chronic liver disease and proline form homozygotes in a report by Yu et al. Our data suggest that proline form homozygotes are associated with invasive bladder cancer.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-0879
    Keywords: Key words Vitamin C ; N-acetyltransferase ; 2-aminofluorene ; DNA adduct ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have already demonstrated the protective role of vitamin C (ascorbic acid) in certain types of cancer. This study reports on the effects of vitamin C on arylamineN-acetyltransferase (NAT) activity and DNA adduct formation in a human bladder tumor cell (T24) line. The activity of NAT was measured using high-performance liquid chromatography (HPLC), by assaying for the amounts of acetylated 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) and the remaining amounts of AF and PABA. T24 cells were used for examining NAT activity and carcinogen–DNA adduct formation. The results demonstrated that NAT activity and 2-aminofluorene–DNA adduct formation in T24 cells were inhibited and decreased by vitamin C in a dose-dependent manner. The apparent kinetic parameters (apparent values ofK m and V max) from T24 cells were also determined with and without vitamin C cotreatment. The data also indicated that vitamin C decreased the apparent values of K m and V max from T24 cells.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 85 (1995), S. 727-739 
    ISSN: 1573-2878
    Keywords: Large-scale dynamical systems ; time-varying delays ; decentralized state feedback controllers ; uncertain parameters ; robustness ; sufficient conditions ; algebraic Riccati equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of the robust stability of large-scale dynamical systems including delayed states and parameter perturbations in interconnections is considered. By using algebraic Riccati equations and some analytical methods, some sufficient conditions on linear decentralized state feedback controllers are derived so that the systems remain stable in the presence of delayed states and parameter perturbations. Such conditions give some bounds on the perturbations of interconnections with delayed states and uncertain parameters, and result in a quantitative measures of robustness for large-scale dynamical systems including delayed states and uncertain parameters in interconnections. The results obtained in this paper are applicable not only to large-scale systems with multiple time-varying delays, but also to large-scale systems without exact knowledge of the delays, i.e., large-scale systems with uncertain delays.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 100 (1999), S. 59-87 
    ISSN: 1573-2878
    Keywords: Large-scale interconnected systems ; nonlinear systems ; time-varying delays ; decentralized state feedback controllers ; stabilization ; generalized dynamical systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The problem of the decentralized stabilization of a class of large-scale nonlinear and linear systems including time-varying delays in the interconnections is considered. By combining the Razumikhin-type theorem with the Lyapunov stability theory, we propose a class of decentralized state feedback controllers which can guarantee always some type of stability of large-scale time-delay systems. In this paper, we assume that the time-varying delays are continuous and bounded nonnegative functions. Furthermore, since the proposed decentralized state feedback controllers are independent of the delays, the results obtained in this paper are applicable to systems without exact knowledge of the delays, i.e., systems with perturbed delays. Finally, a numerical example is given to demonstrate the validity of the results.
    Type of Medium: Electronic Resource
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