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  • 21.60−n  (1)
  • Automatic phonatory control system  (1)
  • BRCA1  (1)
  • 1
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Laryngeale Doppelventilfunktion ; Phonatorische Regelkreissteuerung ; Heiserkeitsdiagramm ; Phonatorische Kompensation ; Funktionale Stimmrehabilitation ; Key words Laryngeal double valve function ; Automatic phonatory control system ; Hoarseness diagramm ; Phonatory compensation ; Functional voice rehabilitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary According to Negus and Pressman the sphincter systems of the vocal folds and the ventricular folds form a respiratory ”laryngeal double valve function”. Correspondingly, we found a physiological phonation system of the glottis and a pathological-compensatory one of the supraglottis. They appear to be regulated through an automatic phonatory control system with the glottal phonatory function evidently acting as sensor level. In order to confirm this hypothesis, objective voice analyses with glottal-relevant parameters of 26 voice-rehabilitated patients after minimally invasive laser surgery of glottal carcinomas are presented and integrated into a ”hoarseness diagram” with the coordinates roughness and breathiness. Using statistically deliminated acoustic clusters, our data show a qualitative hierarchy of different postoperative phonation mechanisms. They demonstrate the influence of the vibratory capacity of glottal and supraglottal structures on the quality of the vibratory closure. Both functional parameters evidently determine the resulting voice quality in the sense of our hypothesis.
    Notes: Zusammenfassung Nach Negus bzw. Pressman bilden die Sphinktersysteme der Stimmlippen und Taschenfalten eine „laryngeale Doppelventilfunktion”. Entsprechend finden wir ein physiologisches Phonationssystem der Glottis und ein pathologisch-kompensatorisches der Supraglottis. Deren Steuerung scheint über einen Regelkreis zu erfolgen mit offenbar der glottischen Phonationsfunktion als Meßfühler. Zur Bestätigung dieser Hypothese werden objektive Stimmanalysen mit glottisrelevanten Parametern von 26 stimmrehabilierten Patienten nach minimal-invasiver Laserchirurgie glottischer Karzinome demonstriert und in ein „Heiserkeits-Diagramm” mit den Koordinaten Rauhigkeit und Behauchung integriert. Unsere Daten belegen mit statistisch abgrenzbaren akustischen Clustern eine qualitative Hierarchie differenter postoperativer Phonationsmechanismen. Sie zeigen den Einfluß der Schwingungsfähigkeit glottischer bzw. supraglottischer Strukturen auf die Qualität des vibratorischen Schlusses. Beide Funktionsparameter bestimmen offensichtlich die resultierende Stimmqualität im Sinne unserer Hypothese.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 123 (1997), S. 69-70 
    ISSN: 1432-1335
    Keywords: BRCA1 ; Mutations ; Phenotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract More than 100 mutations have been described for the breast-cancer-susceptibility geneBRCA1. The paper describes phenotypical aspects of three selected mutations located at the beginning, in the middle, and at the end of the gene. A remarkable decrease of the age of diagnosis of the mammary carcinoma is observed with increasing length of the putative gene product, combined with greater severity of the disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 339 (1991), S. 435-444 
    ISSN: 1434-601X
    Keywords: 21.60−n ; 23.40−s ; 23.40.Hc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Nuclear matrix elements of the two-neutrino and neutrinolessββ decays of48Ca(0 g.s. + )→48Ti(0 g.s. + ) are calculated by shell model and QRPA. The two-neutrino matrix elementM GT 2v is rather reliably evaluated in the QRPA approach by a careful fit of the particle-particle interaction strength in the 1+ channel, which governs the spinisospin ground-state correlations. The shell-model value ofM GT 2v depends not only on the 1+ interaction but largely on the pairing and quadrupole interactions. Concerning the neutrinoless-mode nuclear matrix elements, the shell model gives generally smaller values than the QRPA. A detailed analysis indicates that the discrepancies originate mainly from the truncation of shell-model configurations (fp-space). The QRPA calculation in a larger model space well takes into account transitions from/to single-particle orbits far from the Fermi surface, and those transitions give rise to sizable contributions because of large momentum transfers due to the exchange of a virtual neutrino.
    Type of Medium: Electronic Resource
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