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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical findings in blood of aged patients with femoral neck fractures: A contribution to the detection of occult osteomalacia (1982)
    Springer
    Calcified tissue international 34 (1982), S. 465-469 
    Details
    ISSN: 1432-0827
    Keywords: Femoral neck fracture ; Aging ; Blood biochemical data ; 25-hydroxycholecalciferol ; Serum albumin ; Osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary A study was made in Geneva of 44 patients with femoral neck fractures and no risk factor of osteomalacia to determine concentrations of 25OHD3, calcium, phosphorus, alkaline phosphatase, albumin, and globulins in blood. The results were compared with those obtained for control groups of adult and aged subjects, as well as of 21 subjects operated on for hip osteoarthritis. For the detection of occult osteomalacia, femoral head bone tissue from 14 patients with fractures was examined by histomorphometric methods. In more than a third of the cases, 25OHD3 and serum albumin values were lower than those found for adult and even aged control subjects. Some slight histological signs of osteomalacia were observed in 1 patient with a femoral neck fracture, but there was no correlation between the histologic and the blood data. In practice, when dealing with aged people with no obvious risk of osteomalacia, it is important that a systematic antiosteomalacia treatment consisting of large supplements of vitamin D be avoided and that the conditions of diet and living be carefully controlled.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02411286
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural and cytochemical aspects of the initial phases of an experimental cutaneous calcinosis (calcergy) in the rat (1980)
    Springer
    Cell & tissue research 212 (1980), S. 185-202 
    Details
    ISSN: 1432-0878
    Keywords: Calcergy ; Calcification ; Cutaneous calcinosis ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In rats a subcutaneous injection of KMnO4 leads to the calcification of the connective tissue. During mineral deposition, both intra- and extracellular changes are observed in the connective tissue. The intracellular phase is characterized by the formation of intramitochondrial granules and cytoplasmic vesicles, both in fibroblastic and extrinsic cells. In the extracellular phase, numerous heterogeneous matrix vesicles appear in the extracellular matrix. At the same time, globular particles which are resistant to microincineration, are observed between the collagen fibrils. The mineralization of the extracellular matrix takes place in two stages. The first stage comprises the appearance of needle-like structures and round aggregates. The needle-like structures are observed occasionally in the matrix vesicles and often in the extracellular matrix where they appear isolated or diverging from a central point. The round aggregates, composed of dense particles, are seen in the ground substance between the collagen fibrils. The second stage is characterized by a progressive mineralization of the collagen fibrils and the elastic fibers, without formation of extended calcified plaques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233954
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural study of the long-term development of two experimental cutaneous calcinoses (topical calciphylaxis and topical calcergy) in the rat (1987)
    Springer
    Cell & tissue research 247 (1987), S. 525-532 
    Details
    ISSN: 1432-0878
    Keywords: Calcergy ; Calciphylaxis ; Cutaneous calcinosis ; Experimental calcification ; Ultrastructure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Skin calcification induced by topical calciphylaxis was provoked by a subcutaneous injection of iron chloride in rats previously sensitized by dihydrotachysterol. A cutaneous topical calcergy was induced by an injection of potassium permanganate. An electron-microscopical study of the long-term evolution of both these models of calcification was made. After the initial stages, mineralization of the connective tissue continued by a secondary nucleation process without matrix vesicles. The mineral composed of needle-like structures, apatite in nature, was mainly deposited between and around collagen fibrils, and showed various arrangements in calcified plaques. Intrafibrillar calcification was rarely observed and appeared only in the later stages. The extension of calcified deposits then stopped. Finally, there was a fragmentation of the mineralized area which was progressively surrounded by uncalcified collagen fibrils. A demineralization process, caused by cells such as macrophages and multinucleated giant cells, rather than a resorption of the calcified deposits, was noted. It is important to emphasize that, in both models of ectopic calcification, an evolution toward ectopic ossification was never observed, which is perhaps due to the absence of extensive resorption mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215745
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    Paper (German National Licenses)
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