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  • Clorgyline  (2)
  • dopamine  (2)
  • 25.70.Np  (1)
  • Anxiety  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline (1988)
    Springer
    Psychopharmacology 95 (1988), S. 313-317 
    Details
    ISSN: 1432-2072
    Keywords: Food intake ; Locomotor activity ; Fenfluramine ; Clorgyline ; Long-term ; Suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of fenfluramine to rats produced decreases in 1-h food intake and locomotor activity. Short-term (2–6 days) or long-term (21–25 days) treatment with the monoamine oxidase (MAO) type A inhibiting antidepressant clorgyline potentiated fenfluramine-induced suppression of food intake but did not affect fenfluramine-induced suppression of locomotor activity. Although daily (4 h) food intake was not significantly less in clorgyline-treated animals relative to saline-treated controls, body weight gain was significantly less in clorgyline-treated animals relative to controls. These findings demonstrate a differential effect of clorgyline treatment on fenfluramine-induced suppression of food intake and locomotor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181939
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments (1989)
    Springer
    Psychopharmacology 97 (1989), S. 269-274 
    Details
    ISSN: 1432-2072
    Keywords: m-CPP ; Temperature ; Clorgyline ; Clomipramine ; Imipramine ; Antidepressant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of the serotonin agonist m-chlorophenylpiperazine to rats produced a dose-related hyperthermia. Pretreatment with the serotonin receptor antagonist metergoline totally abolished this response, whereas similar treatment with haloperidol, phenoxybenzamine, naloxone, clonidine, pindolol, propranolol, methiotepin, and ritanserin was ineffective. In studies investigating the modification of the response by antidepressant treatments both acute (3 day) and chronic (22 day) administration of the MAO inhibitor clorgyline, as well as the tricyclics clomipramine and imipramine, attenuated the hyperthermic response to m-CPP. These findings are discussed with regard to the specificity of m-CPP-induced hyperthermia and its subsequent modification by antidepressant treatments, in order to evaluate this model's use as a probe for assessment of the serotonergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442262
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  • 3
    Electronic Resource
    Electronic Resource
    Behavioral, physiological and neuroendocrine responses in healthy volunteers to m-chlorophenylpiperazine (m-CPP) with and without ondansetron pretreatment (1997)
    Springer
    Psychopharmacology 130 (1997), S. 91-103 
    Details
    ISSN: 1432-2072
    Keywords: Key words Serotonin receptors ; Anxiety ; Temperature ; Blood pressure ; Adrenocorticotropic hormone ; Cortisol ; Growth hormone ; Prolactin ; Norepinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several serotonin3 (5-HT3) antagonists have been shown to attenuate the anxiogenic effects of the serotonergic agent, m-chlorophenylpiperazine (m-CPP), in animal models, but little data regarding possible effects of 5-HT3 antagonists on responses to m-CPP are available from studies in humans. Therefore, we studied the behavioral, physiological and neuroendocrine responses of 12 healthy volunteers to IV administered placebo and m-CPP (0.08 mg/kg), with and without IV pretreatment with the selective 5-HT3 antagonist, ondansetron (0.15 mg/kg). Compared to placebo, m-CPP given alone significantly increased ratings of anxiety and several other behavioral measures. m-CPP also produced statistically significant increases in temperature, systolic and diastolic blood pressure, heart rate, and in plasma concentrations of adrenocorticotropic hormone, cortisol, prolactin and norepinephrine. Responses to ondansetron given alone were no different from those of placebo. Pretreatment with ondansetron did not affect peak behavioral responses to m-CPP, but was associated with a significantly earlier return to baseline levels of ratings of anxiety and functional deficit as well as a summary measure of overall behavioral effects. Following ondansetron pretreatment, the increases produced by m-CPP in systolic and diastolic blood pressure and heart rate were no longer significantly different from placebo. Ondansetron pretreatment significantly reduced their plasma cortisol response to m-CPP without affecting the other plasma hormone responses. Plasma concentrations of m-CPP were unaffected by ondansetron pretreatment. These findings suggest that in normal human subjects some behavioral, cardiovascular and neuroendocrine effects of m-CPP may be partially modulated by 5-HT3 receptor-mediated mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050215
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  • 4
    Electronic Resource
    Electronic Resource
    Neuronal protective and rescue effects of deprenyl against MPP+ dopaminergic toxicity (1995)
    Springer
    Journal of neural transmission 100 (1995), S. 53-61 
    Details
    ISSN: 1435-1463
    Keywords: Deprenyl (selegiline) ; MPTP ; MPP+ ; Parkinson's disease ; dopamine ; substantia nigra ; nigrostriatal neuron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intranigral infusion of 1-Methyl-4-phenylpyridinium ion (MPP+, 2.1–16.8 nmol) dose-dependently injured nigral neurons as reflected by reduced dopamine levels in the ipsilateral striatum four days after the infusion of this toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Coadministration of deprenyl (4.2 nmol) with MPP+ into the substantia nigra protected against MPP+-induced moderate (20–50%) but not severe (over 70%) nigral injury as reflected in striatal dopamine reductions. However, supplementary treatment with deprenyl (0.25 mg/kg, s.c., twice daily for 4 days) after intranigral infusion of MPP+ significantly rescued nigral neurons from more severe damage caused by a higher MPP+ does (8.4 nmol) manifested by a lesser striatal dopamine decrease (−31%) compared to the non-deprenyl treated group (−70%). Thus, in addition to the blockade of bioactivation of MPTP, deprenyl can protect and/or rescue nigral neurons from MPP+-induced dopaminergic neurotoxicity. These in vivo data add further evidence to suggest that deprenyl, a putative and clinically unproven neuroprotective agent, may be of value in slowing the progressive nigral degeneration in “early” Parkinson's disease, but may prove to be less so in its terminal stages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276865
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  • 5
    Electronic Resource
    Electronic Resource
    Plasma amine oxidase activities in Norrie disease patients with an X-chromosomal deletion affecting monoamine oxidase (1991)
    Springer
    Journal of neural transmission 83 (1991), S. 1-12 
    Details
    ISSN: 1435-1463
    Keywords: Benzylamine ; dopamine ; serotonin ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two individuals with an X-chromosomal deletion were recently found to lack the genes encoding monoamine oxidase type A (MAO-A) and MAO-B. This abnormality was associated with almost total (90%) reductions in the oxidatively deaminated urinary metabolites of the MAO-A substrate, norepinephrine, and with marked (100-fold) increases in an MAO-B substrate, phenylethylamine, confirming systemic functional consequences of the genetic enzyme deficiency. However, urinary concentrations of the deaminated metabolites of dopamine and serotonin (5-HT) were essentially normal. To investigate other deaminating systems besides MAO-A and MAO-B that might produce these metabolites of dopamine and 5-HT, we examined plasma amine oxidase (AO) activity in these two patients and two additional patients with the same X-chromosomal deletion. Normal plasma AO activity was found in all four Norrie disease-deletion patients, in four patients with classic Norrie disease without a chromosomal deletion, and in family members of patients from both groups. Marked plasma amine metabolite abnormalities and essentially absent platelet MAO-B activity were found in all four Norrie disease-deletion patients, but in none of the other subjects in the two comparison groups. These results indicate that plasma AO is encoded by gene(s) independent of those for MAO-A and MAO-B, and raise the possibility that plasma AO, and perhaps the closely related tissue AO, benzylamine oxidase, as well as other atypical AOs or MAOs encoded independently from MAO-A and MAO-B may contribute to the oxidative deamination of dopamine and 5-HT in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244447
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  • 6
    Electronic Resource
    Electronic Resource
    Measurements ofn−p correlations in the reaction of relativistic neon with uranium (1986)
    Springer
    The European physical journal 323 (1986), S. 391-398 
    Details
    ISSN: 1434-601X
    Keywords: 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report a preliminary measurement of coincident neutron-proton pairs emitted at 45° in the interaction of 400, 530, and 650 MeV/A neon beams incident on uranium. Charged particles were identified by time of flight and momentum, as determined in a magnetic spectrometer. Neutral particles were detected using a thick plastic scintillator, and their time of flight was measured between an entrance scintillator, triggered by a charged particle, and the neutron detector. The scatter plots and contour plots of neutron momentum vs. proton momentum appear to show a slight correlation ridge above an uncorrelated background. The projections of this plane on then-p momentum difference axis are essentially flat, showing a one standard deviation enhancement for each of the three beams energies. At each beam energy, the calculated momentum correlation function for the neutron-proton pairs is enhanced near zero neutron-proton momentum difference by approximately one standard deviation over the expected value for no correlation. This enhancement is expected to occur as a consequence of the attractive final state interaction between the neutron and proton (i.e., virtual or “singlet” deuterons). The implications of these measurements are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313520
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