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Digitale Medien

Acquired alterations in vitamin D metabolism in the acidotic state (1982)

Baran, Daniel T. ; Lee, Sook Won ; Jo, O. D. ; [weitere]

Springer

Calcified tissue international 34 (1982), S. 165-168

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Details

ISSN: 1432-0827

Schlagwort(e): Acidosis ; 25OHD3 ; 1,25(OH)2D3 ; Chicks ; Rickets

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin , Physik

Notizen: Summary Classic (type I) renal tubular acidosis in children is attended by growth retardation and rickets, abnormalities that can be corrected by alkali therapy alone. We have employed the NH4Cl-treated rachitic chick as a model to investigate vitamin D metabolism in the acidotic state. NH4Cl ingestion for 96 h was associated with a rise in serum calcium, a significant decrease in blood pH (7.42+0.08 vs 7.30±0.08,P〈0.005), decreased [3H]1,25(OH)2D3 following [3H]25OHD D3 injections, and enhanced metabolic clearance of administered [3H]1,25(OH)2D3. The data collectively suggest that metabolic acidosis in the chick alters the production and degradation of 1,25(OH)2D3.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02411228

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