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  • 1
    Electronic Resource
    Electronic Resource
    Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene (1979)
    Springer
    Archives of toxicology 43 (1979), S. 135-140 
    Details
    ISSN: 1432-0738
    Keywords: Aldehyde dehydrogenase ; Enzyme induction ; Phenobarbital ; 3-Methylcholanthrene ; Genetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of the enzyme to PB or 3-MC was observed. In rats of the Wistar strain the enzyme activity remained unchanged (“non-responsive”) in all rats after treatment with PB while it increased (“responsive”) 5- to 19-fold in all rats after treatment with 3-MC. The enzyme activity increased 8- to 20-fold and 2- to 8-fold respectively after treatment with PB and 3-MC in all rats of the Long-Evans strain. In rats of the Sprague-Dawley strain the enzyme activity remained unchanged in half of all the rats treated with PB or 3-MC and increased 2- to 7-fold over the basal level in half of the treated rats. The non-responsive rats to PB were all responsive to 3-MC treatment while the responsive rats to PB were responsive in 65% and non-responsive in 35% to 3-MC treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333620
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Posttraumatic Stress Disorder and Substance Abuse: Use of Research in a Clinical Setting (1997)
    Springer
    Journal of traumatic stress 10 (1997), S. 141-148 
    Details
    ISSN: 1573-6598
    Keywords: posttraumatic stress disorder ; substance abuse ; inpatient ; assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract The goal of the present investigation was to evaluate whether the process of assessing posttraumatic stress disorder (PTSD) in substance abuse/dependence inpatients (N = 95) as part of a research protocol influenced the diagnostic assessment conducted by clinical staff. The prevalence of current crime-related PTSD (CR-PTSD) observed with a research interview was 40% (n = 38), whereas the rate of current CR-PTSD documented in (the same) patients' discharge summaries was 15% (n = 14). An even lower CR-PTSD prevalence rate of 8% (n = 5) was obtained from a new sample of patient discharge summaries (N = 59) collected after the cessation of the research project. On chart intake reports, clinical staff documented a history of sexual and/or physical assault in approximately one-half of these patients, but PTSD was not evaluated. PTSD appears to be under-diagnosed by clinical staff in patients with substance use disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1024872800683
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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