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  • 1
    Electronic Resource
    Electronic Resource
    BRADYKININ-INDUCED VASCULAR RESPONSES IN DOG ISOLATED LINGUAL ARTERY (1999)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 26 (1999), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Kinin-induced vascular responses were studied and kinin receptor subtypes were characterized in canine isolated and preconstricted lingual arteries.2. A low dose of bradykinin (BK; 〈 3 × 10–14 mol) induced only vasodilation, while a higher dose of BK (〉 3 × 10–13 mol) frequently induced a biphasic response: a transient constriction followed by dilation.3. The BK-induced vasodilation was mostly endothelium dependent but was also partly endothelium independent because although the dilation response was greatly reduced after removal of the endothelium, it was not completely abolished.4. The dilation response to BK was significantly inhibited by the B2 kinin receptor antagonist HOE 140 and was partly reduced by indomethacin (10 μmol/L) (P 〈 0.05).5. Bradykinin-induced vasoconstriction was enhanced in endothelium-denuded preparations. The constriction was significantly inhibited by HOE 140 (10–10 mol/L). The BK-induced responses were not affected by the B1 kinin receptor antagonist des-Arg9-[Leu8]-BK (3 × 10–11 mol/L).6. The B1 kinin receptor agonist des-Arg9-BK (〉 10–12 mol/L) produced vasodilation in 60% of endothelium-intact preparations. In 20% of the endothelium-intact preparations des-Arg9-BK produced a biphasic response: weak vasoconstriction followed by weak vasodilation. The des-Arg9-BK-induced dilation and constriction were significantly inhibited by des-Arg9-[Leu8]-BK (3 × 10–11 mol/L), but were not affected by HOE 140 (10–10 mol/L).7. In conclusion, it appears that both B1 and B2 kinin receptors are present in the dog lingual artery. Both receptor subtypes mediate either vasodilation or vasoconstriction and BK-induced vasodilation is mostly endothelium dependent, although it may also be partially prostaglandin dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.1999.03057.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect Of Temperature On Responses Of Dog Isolated Lingual And Mesenteric Arteries To Vasoactive Substances (2000)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 27 (2000), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of temperature on submaximal vasoconstriction to an intraluminal administration of noradrenaline (NA), phenylephrine, tyramine and KCl were investigated in canine isolated and perfused lingual and mesenteric arteries, using the cannula-inserting method.2. In lingual arteries, cooling (from 37 to 27°C) caused significant depression of vasoconstriction to the four vasoactive substances used. Rewarming (to 37°C) induced a significant augmentation of constriction by NA, phenylephrine and KCl, but not tyramine.3. In mesenteric arteries, cooling depressed tyramine- and KCl-induced constrictions, but had no effect on NA- and phenylephrine-induced vasoconstriction. Only in the case of KCl-induced constrictions did rewarming induce a potentiation of the vasoconstrictor response.4. We conclude that: (i) cooling induces a depression of voltage-dependent Ca2+ channels and rewarming may induce a potentiation of Ca2+ channels in both arteries; (ii) α1- adrenoceptor-operated Ca2+ channels are depressed by cooling in lingual arteries but not in mesenteric arteries; and (iii) cooling may induce an attenuation of the re-uptake function in sympathetic nerve terminals in both arteries and this attenuation may be not rapidly restored by acute rewarming.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.2000.03352.x
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  • 3
    Electronic Resource
    Electronic Resource
    POSSIBLE INVOLVEMENT OF MUSCARINIC M1 AND M3 RECEPTOR SUBTYPES MEDIATING VASODILATION IN ISOLATED, PERFUSED CANINE LINGUAL ARTERIES (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Using the cannula insertion method, muscarinic receptor subtypes were analysed in isolated, perfused canine lingual arteries preconstricted with phenylephrine.2. Both acetylcholine and McN-A-343 induced a profound vasodilation in a dose-related manner. Acetylcholine-induced dilations were approximately 1000-times more potent than McN-A-343-induced dilation.3. Acetylcholine-induced dilations were abolished after removal of the endothelium by intraluminal treatment with 1 mg saponin.4. Acetylcholine-induced dilations were markedly inhibited by an M1/M3 receptor antagonist, 4-DAMP. Moreover, they were slightly, but significantly, inhibited by an M1 antagonist, pirenzepine, but never influenced by an M2 antagonist, AF-DX 116. Mc-N-A-343-induced vasodilations were inhibited by both 4-DAMP or pirenzepine.5. These results suggest that there are abundant functional M3 and a few M1 receptors in the canine lingual artery that mediate vasodilation and that this vasodilation is dependent on the presence of an intact endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb01189.x
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  • 4
    Electronic Resource
    Electronic Resource
    Acetaldehyde level in the blood and liver aldehyde dehydrogenase activities in trichloroethylene-treated rats (1978)
    Springer
    Archives of toxicology 41 (1978), S. 207-214 
    Details
    ISSN: 1432-0738
    Keywords: Trichloroethylene ; Ethanol metabolism ; Acetaldehyde ; Aldehyde dehydrogenases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The liver NAD+-dependent aldehyde dehydrogenase (AldDH) activity and the acetaldehyde level in the blood during ethanol metabolism after trichloroethylene (trichlene) exposure were studied in rats. Trichlene inhalation caused large elevations in acetaldehyde levels during ethanol metabolism and caused decreases in the activity of the AldDH with a low Km value in mitochondrial and soluble fractions of liver cells. No significant effects were found in the activity of the high Km-enzyme in mitochondrial, soluble and microsomal fractions. Time course of inhibition of the mitochondrial low Km-enzyme and that of elevations in acetaldehyde levels during ethanol metabolism after trichlene exposure were similar. These findings suggest that acetaldehyde formed from ethanol in vivo is oxidized primarily by the mitochondrial low Km-enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354092
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic control of responsiveness of rat liver supernatant aldehyde dehydrogenase to phenobarbital and 3-methylcholanthrene (1979)
    Springer
    Archives of toxicology 43 (1979), S. 135-140 
    Details
    ISSN: 1432-0738
    Keywords: Aldehyde dehydrogenase ; Enzyme induction ; Phenobarbital ; 3-Methylcholanthrene ; Genetic control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of the enzyme to PB or 3-MC was observed. In rats of the Wistar strain the enzyme activity remained unchanged (“non-responsive”) in all rats after treatment with PB while it increased (“responsive”) 5- to 19-fold in all rats after treatment with 3-MC. The enzyme activity increased 8- to 20-fold and 2- to 8-fold respectively after treatment with PB and 3-MC in all rats of the Long-Evans strain. In rats of the Sprague-Dawley strain the enzyme activity remained unchanged in half of all the rats treated with PB or 3-MC and increased 2- to 7-fold over the basal level in half of the treated rats. The non-responsive rats to PB were all responsive to 3-MC treatment while the responsive rats to PB were responsive in 65% and non-responsive in 35% to 3-MC treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333620
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  • 6
    Electronic Resource
    Electronic Resource
    Enhancement of vasoconstrictor responses to thiopental and barium chloride by intraluminal treatment with saponin in isolated canine mesenteric arteries (1986)
    Springer
    Heart and vessels 2 (1986), S. 102-105 
    Details
    ISSN: 1615-2573
    Keywords: Isolated perfused artery ; Cannula insertion method ; Vasoconstriction ; Thiopental ; Endothelium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a cannula-insertion method for isolated arteries, the effects of thiopental, barium chloride, and prostaglandin F2α were investigated on isolated canine mesenteric arteries with and without saponin treatment. Thiopental caused a vasoconstriction in a dose-related manner. The observed vasoconstriction was not influenced by phentolamine in doses which inhibited norepinephrine-induced vasoconstriction. After intraluminal saponin treatment, thiopental- and barium chloride-induced constrictions were significantly enhanced, but prostaglandin F2α-induced constriction was not potentiated. It is suggested that vasoconstrictor responses to thiopental and barium chloride may be enhanced by an increase in calcium influx after disrupting the endothelium of the artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02059963
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  • 7
    Electronic Resource
    Electronic Resource
    Vasoconstrictor effects of endogenous digitalis-like factors extracted from urine of hypertensive patients (1987)
    Springer
    Heart and vessels 3 (1987), S. 129-134 
    Details
    ISSN: 1615-2573
    Keywords: Endogenous digitalis-like factors ; Isolated dog intermediate auricular artery ; Cannula inserting method ; Vasoconstriction ; Verapamil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The vascular effects of endogenous digitalis-like factors (EDLFs) extracted from the urine of hypertensive patients were investigated in isolated and perfused intermediate auricular and mesenteric arterial preparations of dogs. EDLFs produced a transient vasoconstriction in a dose-related manner in intermediate auricular arteries but only a slight constriction in mesenteric arteries. Ouabain induced a long-lasting vasoconstriction with tachyphylaxis in intermediate auricular arteries, but it did not constrict mesenteric arteries. EDLF-induced vasoconstrictions were reproducible and were not modified by alpha-adrenoceptor blockade. They were slightly suppressed by a potent calcium entry blocker, verapamil, in doses which markedly suppressed KCl-induced vasoconstrictions. Noradrenaline- and KCl-induced vasoconstrictions were not significantly modified by either EDLF or ouabain. From these results, it is concluded that EDLF has clear vasoconstrictor properties which are not due to adrenergic or calcium entry mechanisms and that there are differences in the vasoconstrictor effects of EDLFs with respect to different vascular beds. This is similar to what was found with ouabain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058788
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  • 8
    Electronic Resource
    Electronic Resource
    Histamine-induced vasodilations mediated by H1- and H2-receptors in isolated rat common carotid arteries (1991)
    Springer
    Heart and vessels 6 (1991), S. 185-190 
    Details
    ISSN: 1615-2573
    Keywords: Histamine-induced dilation ; Histamine receptor subtype ; Cannula inserting method ; Isolated rat common carotid artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the cannula inserting method, the vasodilatory effects of histamine were analysed employing selective histamine H1- and H2-receptor agonists and antagonists in isolated, perfused rat common carotid arterial preparations which were preconstricted by a continuous infusion of phenylephrine with propranolol. Histamine, 2-pyridylethylamine (2-PEA) (a selective H1-agonist) and dimaprit (a selective H2-agonist) produced a vasodilation in a dose-related manner. The order of potency was histamine 〉 dimaprit 〉 2-PEA. Histamine-induced dilations were significantly inhibited by either diphenhydramine (a selective H1-antagonist) or cimetidine (a selective H2-antagonist). 2-PEA-induced dilations were significantly inhibited by diphenhydramine but not by cimetidine. Dimaprit-induced dilations were significantly blocked by cimetidine but not by diphenhydramine. ACh-, histamine-, 2-PEA- and dimaprit-induced dilations were significantly suppressed by removal of the endothelium. From these results, it is concluded that (1) isolated rat common carotid arteries have both H1-and H2-receptors, (2) there are few vasoconstrictory H1-receptors, (3) both H1- and H2-receptors mediate only vasodilation but not vasoconstriction, and (4) EDRF from the endothelium might participate in histamine-induced vasodilation via not only H1- but also H2-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02125095
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for the existence of postsynaptic beta-1 and beta-2 adrenoceptors in isolated simian facial veins (1991)
    Springer
    Heart and vessels 6 (1991), S. 168-174 
    Details
    ISSN: 1615-2573
    Keywords: Cannula inserting method ; Simian facial vein ; Vasodilation ; Dominant beta-adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With the use of a steel cannula inserting method, the actions of the beta-adrenoceptor agonists, noradrenaline (NA, a mixed agonist), isoprenaline (a mixed agonist), dobutamine (a selective beta-1 agonist), salbutamol, and procaterol (selective beta-2 agonists), were investigated on isolated and perfused simian facial veins. Each beta-agonist usually induced a vasodilation in a dose-related manner in non-preconstricted vessel preparations. The rank order of potency was isoprenaline ≫ NA 〉 dobutamine 〉 salbutamol 〉 procaterol. NA- and isoprenaline-induced vasodilations were inhibited by either metoprolol (a selective beta-1 adrenoceptor antagonist) or ICI 118,551 (a selective beta-2 antagonist). After beta-1 blockade, NA produced a vasoconstriction which was readily blocked by bunazosin (an alpha-1 antagonist). Dobutamine-induced vasodilations were strongly suppressed by metoprolol and slightly blocked by ICI 118,551. Salbutamol-induced vasodilations were blocked by metoprolol, while ICI 118,551 more markedly inhibited these dilations. From these results, it was concluded that there are abundant beta-adrenoceptors and predominantly beta-1 adrenoceptors in isolated simian facial veins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058282
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  • 10
    Electronic Resource
    Electronic Resource
    Comparison of vasoconstrictor actions of norepinephrine and potassium chloride before and after damage of endothelium by saponin (1986)
    Springer
    Heart and vessels 2 (1986), S. 1-5 
    Details
    ISSN: 1615-2573
    Keywords: Isolated perfused artery ; Cannula inserting method ; Endothelium ; Saponin ; KCl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using isolated and perfused mesenteric arterial preparations of dogs, vasoconstrictor responses to intraluminal norepinephrine and potassium chloride were investigated in the presence and absence of the endothelium. Intraluminal administration of saponin readily removed the endothelium. Saponin (1–3 mg) caused an increase in perfusion pressure, and then approximately 20 min later perfusion pressure became stable at a somewhat higher level than that of the control. A larger dose of saponin (10 mg) caused a tremendous but temporary increase of perfusion pressure. KCl-induced vasoconstriction was significantly enhanced by pretreatment with 0.3, 1, and 3 mg saponin, but norepinephrine-induced constriction was not modified significantly. Moreover, it was demonstrated that diltiazem, a potent Ca antagonist, inhibited the KCl-induced vasoconstriction more readily in the absence than in the presence of the endothelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060237
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