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  • 1
    Electronic Resource
    Electronic Resource
    Action of dopamine and serotonin on the membrane potential of cultured astrocytes (1987)
    Springer
    Experimental brain research 65 (1987), S. 482-485 
    Details
    ISSN: 1432-1106
    Keywords: Electrophysiology ; Dopamine ; Serotonin ; Astrocytes ; Tissue cultures ; Spinal cord ; Striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The actions of dopamine, apomorphine and serotonin on the membrane potential of cultured astrocytes from rat spinal cord and striatum were examined. All three compounds caused a hyperpolarization of the majority of astrocytes tested. A small number of cells was depolarized and on a relatively large number of cells the amines had no effect. The dopamine antagonists cis-flupenthixol and domperidone reversibly blocked the effects of dopamine whereas the action of serotonin was antagonized by ketanserin. It is therefore concluded that the effects of both amines are due to activation of specific dopamine and serotonin receptors, respectively. Our electrophysiological data together with autoradiographic binding studies provide evidence that astrocytes possess receptors for dopamine and serotonin in addition to adrenoceptors and histamine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236323
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Autoradiographic localization of binding sites for 3H-serotonin and 3H-ketanserin on neurones and astrocytes of cultured rat brain stem and spinal cord (1987)
    Springer
    Experimental brain research 65 (1987), S. 486-490 
    Details
    ISSN: 1432-1106
    Keywords: Binding ; Autoradiography ; 3H-serotonin ; 3H-ketanserin ; Tissue culture ; Brain stem ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By means of lightmicroscopic autoradiography we have studied the cellular localization of binding sites for 3H-serotonin and 3H-ketanserin in organotypic cultures of rat brain stem and spinal cord. In both types of cultures, a relatively great number of neurones revealed binding sites for 3H-serotonin which predominantly labels S1-receptors. 3H-ketanserin, an S2-antagonist was also bound to many neurones although to a lesser extent than 3H-serotonin. Binding sites for both radio-ligands were also observed on astrocytes. These findings together with electrophysiological investigations indicate that astrocytes possess serotonin receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236324
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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