ISSN:
1432-1041
Keywords:
debrisoquine
;
psoriasis
;
chronic discoid psoriasis
;
4-hydroxylation
;
microsomal oxidation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary 1. The 4-hydroxylation of debrisoquine was measured in 42 patients with chronic discoid psoriasis. 2. The proportion of poor metabolisers (4.8%) and the median metabolic ratio (0.5) in psoriatics were similar to that reported previously in a healthy British population. 3. We conclude that the abnormality of microsomal mono-oxygenase activity which we have found in the skin and other tissues of psoriatics is not due to a generalised (non-specific) impairment of microsomal oxidation and may be enzyme specific.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00627929
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