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  • 1
    Electronic Resource
    Electronic Resource
    Preparation and NMR spectra of B5H9Fe(CO)3, an analog of hexaborane(10) (1979)
    s.l. : American Chemical Society
    Inorganic chemistry 18 (1979), S. 670-673 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50193a028
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of solutions for atomic absorption analyses of iron, manganese, zinc, and copper in plant tissue (1974)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 22 (1974), S. 103-107 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60191a028
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  • 3
    Electronic Resource
    Electronic Resource
    The Isolation of Sucrose from Soybeans (1937)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 59 (1937), S. 2470-2471 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01290a505
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  • 4
    Electronic Resource
    Electronic Resource
    Oxygen consumption inNeomysis americana (Crustacea: Mysidacea), and the effects of naphthalene exposure (1984)
    Springer
    Marine biology 79 (1984), S. 109-116 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Oxygen uptake ( $$\dot VO{_2}$$ ) of individual mysids was measured in a novel continuous flow respirometer for 24-h periods, and in a sealed chamber respirometer for several hours. Mysids were acclimated 30–100d under conditions which allowed complete life-cycle cultivation. $$\dot VO{_2}$$ was normalized for mysid size using an unconventional linear regression: log ( $$\dot VO{_2}$$ ) vs log (body water). Compared to the conventional regression, log ( $$\dot VO{_2}$$ ) vs log (body mass), the new approach showed two advantages: significantly greater coefficient of determination,r 2, and removal of differences in $$\dot VO{_2}$$ between sexes. Minimum rates of oxygen uptake measured in the continuous flow respirometer were lower than sealed chamber measurements, and may more accurately reflect standard metabolic rate. Hourly data also showed a daily cycle when adjusted to represent a standard size mysid. Exposure to ca 1.1 mg l-1 naphthalene increased $$\dot VO{_2}$$ and the range of spontaneous $$\dot VO{_2}$$ shown by the mysids; exposure to ca 0.1 mgl-1 naphthalene depressed the range of $$\dot VO{_2}$$ . Both exposures caused aberrations in the daily cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00951819
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  • 5
    Electronic Resource
    Electronic Resource
    A theoretical basis for conditional probability analyses of neural discharge activity (1992)
    Springer
    Biological cybernetics 67 (1992), S. 1-10 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A theory has been developed which allows the estimation of the probability density of a discharge, given that an arbitrary condition is fulfilled. It is shown that the common methods for the evaluation of a post-stimulus time (PST) histogram and a hazard function can be considered as special applications of this theory. Whereas the usual hazard function shows how the probability of a discharge depends on the time elapsed since the last discharge, generalized hazard functions proposed in the present paper allow to reveal also the influence of the last but one discharge, the last but two discharge, and so on. In contrast to the usual method for the estimation of a hazard function, the applicability of the procedures proposed here is not restricted to stationary discharge activity. Some elementary applications are illustrated by analysing simulated discharge activity mimicing the response of a single auditory-nerve fiber to a high-intensity tone burst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201797
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  • 6
    Electronic Resource
    Electronic Resource
    Short-term adaptation and incremental responses of single auditory-nerve fibers (1975)
    Springer
    Biological cybernetics 17 (1975), S. 169-182 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract In response to tone bursts of constant sound intensity, mammalian auditory-nerve fibers produce a maximum firing rate at onset, followed by an adaptation to a quasi-steady firing rate within about 150 msec. On the basis of two fundamental findings, it appears that the adaptation is additive, or linear, in nature and does not result from a multiplicative gain change. Basically, a given increment in stimulus intensity produces the same change in firing rate before and after the adaptation. In addition, the relative amount of adaptation, i.e. the ratio of driven onset firing rate to driven steady-state firing rate, is independent of tone intensity. Nonlinear effects that appear in the experimental results may be accounted for by two static nonlinearities, one preceding and one following the linear adaptation stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364166
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  • 7
    Electronic Resource
    Electronic Resource
    Adaptation in auditory-nerve fibers: A revised model (1982)
    Springer
    Biological cybernetics 44 (1982), S. 107-120 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Adaptation of firing rates in auditory-nerve fibers appears to reflect two distinct processes. Rapid adaptation occupies the first few milliseconds of response and is superimposed upon short-term adaptation which has a time constant of about 40 ms. The properties of the two processes are reviewed and compared, and a phenomenological model is developed that successfully accounts for them. The model consists of several stages which have been tentatively associated with underlying physiological processes. In the first stage stimulus intensity is transformed by a static nonlinearity, followed by a low-pass filter. The filtered output may correspond to the hair-cell receptor potential. It modulates the release of a substance that possibly represents synaptic transmitter. Adaptation is produced by the depletion of transmitter which is located in three stores in cascade. A global store with fixed concentration controls the steady-state response and replenishes a local store which is responsible for short-term adaptation. The local store seplenishes a rapidly depleted immediate store. Flow between stores is proportional to concentration gradients with the following exceptions. The immediate store is subdivided into independent volumes or sites and there is no flow among sites or back to the local store. A given site becomes activated only when the receptor potential exceeds its particular activation value and the number of activated sites is proportional to the receptor potential. The flow of transmitter from the immediate store is assumed to be proportional to neural firing rate, with some minor modifications described in the text. The properties of the model are determined from the underlying equations and from a computer simulation. The model produces realistic response properties including PST histograms, onset and steady-state rate-intensity functions, incremental and decremental responses, response modulation for amplitude modulated stimuli, and period histograms for low-frequency tones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00317970
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  • 8
    Electronic Resource
    Electronic Resource
    Differential encoding of rapid changes in sound amplitude by second-order auditory neurons (1985)
    Springer
    Experimental brain research 60 (1985), S. 417-422 
    Details
    ISSN: 1432-1106
    Keywords: Hearing ; Cochlear nucleus ; Dynamic range ; Neural encoding ; Gerbil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single-cell recordings from the anesthetized gerbil revealed that neurons in the ventral cochlear nucleus, the most peripheral nucleus of the central auditory system, differentially encode a functionally relevant acoustic feature — amplitude modulation. Onset units show the strongest phase — locked responses to amplitude-modulated sounds, followed in order by chopper, primarylike-with-notch and primarylike units. All these neurons show enhanced responses relative to auditory-nerve fibers which provide their ascending inputs. This enhancement occurs over a 90 dB range of sound levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235939
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  • 9
    Electronic Resource
    Electronic Resource
    Polymorphic metabolism of the β-adrenoreceptor blocking drugs and its clinical relevance (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 77-84 
    Details
    ISSN: 1432-1041
    Keywords: β-Blockers ; debrisoquine metabolism ; extensive metabolizers ; genetic polymorphism ; poor metabolizers ; glucuronidation ; lipophilicity ; pharmacodynamics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Although β-Blockers are structurally closely related, there are marked differences in the extent of metabolism, related mainly to relative lipophilicity. Lipophilic β-Blockers are metabolized by C-oxidative pathways and glucuronidation. Metabolism of lipophilic β-Blockers is important in determining pharmacokinetics, formation of active metabolites, stereoselectivity and isomer preference, and interphenotypic variation. The oxidative clearance of metoprolol, timolol and bufuralol is regulated/influenced by the debrisoquine hydroxylation gene locus. The metabolism of these lipophilic β-Blockers thus exhibits polymorphic characteristics, there being significant interphenotype differences in pharmacokinetics (bioavailability, peak plasma level, plasma terminal t1/2) between the poor and extensive metabolizers of debrisoquine. There are similar interphenotype differences in β-blocker pharmacodynamics in terms of β-blockade. A number of adverse effects of lipophilic β-Blockers have been hypothesized to predominate in the poor metabolizer phenotype including unacceptable bradycardia, loss of cardioselectivity, greater CNS side-effects, and interactions with drugs metabolized by the same polymorphic systems. However, objective evidence for this is lacking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543715
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  • 10
    Electronic Resource
    Electronic Resource
    Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 257-258 
    Details
    ISSN: 1432-1041
    Keywords: debrisoquine ; psoriasis ; chronic discoid psoriasis ; 4-hydroxylation ; microsomal oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 1. The 4-hydroxylation of debrisoquine was measured in 42 patients with chronic discoid psoriasis. 2. The proportion of poor metabolisers (4.8%) and the median metabolic ratio (0.5) in psoriatics were similar to that reported previously in a healthy British population. 3. We conclude that the abnormality of microsomal mono-oxygenase activity which we have found in the skin and other tissues of psoriatics is not due to a generalised (non-specific) impairment of microsomal oxidation and may be enzyme specific.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627929
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