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  • Polymer and Materials Science  (3)
  • 42.60  (1)
  • B-cell lymphocytes  (1)
  • Blood flow  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Picosecond pulses and applications (1982)
    Springer
    Applied physics 28 (1982), S. 172-179 
    Details
    ISSN: 1432-0649
    Keywords: 42.60 ; 07.65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697843
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-2 correction of defectivein vitro T-cell mitogenesis in patients with common varied immunodeficiency (1984)
    Springer
    Journal of clinical immunology 4 (1984), S. 295-303 
    Details
    ISSN: 1573-2592
    Keywords: Combined varied immunodeficiency ; interleukin-2 ; T-cell lymphocytes ; B-cell lymphocytes ; mitogen response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI). The median values of endogenous IL2 produced by mitogen-stimulated PBL was significantly lower in patients than controls irrespective of the mitogen used. The patients, taken as a group, had a significantly decreasedin vitro PBL response to mitogen stimulation when compared to controls. With the addition of a highly purified human IL2 preparation, the proliferative response in the majority of patients was significantly improved with all mitogens. Three patient groups could be distinguished: Group A (3/14) had full restoration of proliferative response with the addition of IL2, Group B (5/14) had partial restoration, and Group C (6/14) had no significant response. The monoclonal antibody, Pan T2, recognized a T-cell proliferative defect in 5 of 14 patients which neither PHA nor OKT3 recognized. This was not significantly corrected by the addition of IL2. This T-cell proliferative defect correlated with the lack of B-cell proliferation and immunoglobulin production in response to B-cell mitogens in three-fourths of the patients assayed. These data show that CVI patients are a heterogeneous group but have in common a decreasedin vitro production of IL2 resulting in a proliferative defect which is correctable at least in part,in vitro, in the majority by the addition of purified IL2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00915297
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  • 3
    Electronic Resource
    Electronic Resource
    Computationally efficient algorithms for convection-permeation-diffusion models for blood-tissue exchange (1992)
    Springer
    Annals of biomedical engineering 20 (1992), S. 687-725 
    Details
    ISSN: 1573-9686
    Keywords: Blood-tissue exchange ; Capillary permeability ; Pharmacokinetics ; Cellular uptake ; Volumes of distribution ; Interstitial space ; Intracellular consumption ; Organ uptake and washout ; Blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Analysis of data on tissue depositions obtained by positron tomographic or NMR imaging, or of multiple tracer outflow dilution curves, requires fitting data with models composed of aggregates of capillary-tissue units. These units account for heterogeneities of flows and multisolute exchanges between longitudinally distributed regions across capillary and cell barriers within an organ. Because the analytic solutions to the partial differential equations require convolution integration, solutions are obtained relatively efficiently by a fast numerical method. Our approach centers on the use of a sliding fluid element algorithm for capillary convection, with the time step set equal to the length step divided by the fluid velocity. Radial fluxes by permeation between plasma, interstitial fluid, and cells and axial diffusion exchanges within each time step are calculated analytically. The method enforces mass conservation unless there is regional consumption. Solution for a 2-barrier, 3-region model, accurate to within 0.5%, are 100 to 1000 times faster than the corresponding, purely analytic solution, and over 10,000 times for a 4-region model. Applications include multiple indicator dilution studies of kinetics of transcapillary exchange and positron emission tomographic studies of the mechanisms of substrate transport into cells of organsin vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02368613
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  • 4
    Electronic Resource
    Electronic Resource
    A new sensor for the determination of nicotine in tobacco products (1990)
    Weinheim : Wiley-Blackwell
    Electroanalysis 2 (1990), S. 81-84 
    Details
    ISSN: 1040-0397
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A new nicotine sensor for the simple, rapid determination of nicotine in tobacco products without prior separation is described. The sensor is a coated graphite electrode with silicotungstic acid as the active material in polyvinyl chloride with di(2-ethylhexyl) phthalate as the plasticizer. At pH 5.5-6.0, it provides a Nernstian response to nicotine over 10-1 to 10-6 M; the detection limit is 7.4 × 10-7 M, and the average slope is 58 mV/pN. The analytical recovery is 98.1 to 102.3%. Satisfactory results are obtained in comparison with silicotungstate gravimetric method and UV spectrometry.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140020115
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  • 5
    Electronic Resource
    Electronic Resource
    Molecular dynamics simulation of a leucine zipper motif predicted for the integrase of human immunodeficiency virus type I (1994)
    New York : Wiley-Blackwell
    Biopolymers 34 (1994), S. 1027-1036 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We have used the molecular dynamics (MD) simulation package AMBER4 to search the conformation of a peptide predicted as a leucine zipper motif for the human immunodeficiency virus type I integrase protein (HIV IN-LZM). The peptide is composed of 22 amino acid residues and its location is from Val 151 to Leu 172. The searching procedure also includes two known α-helices that served as positive controls - namely, a 22-residue GCN4-p1 (LZM) and a 20-residue poly(L-alanine) (PLA). A 21-residue peptide extracted from a cytochrome C crystal (CCC-t) with determined conformation as a β-turn is also included as a negative control. At the beginning of the search, two starting conformations - namely, the standard right-handed α-helix and the fully stretched conformations - are generated for each peptide. Structures generated as standard α-helix are equilibrated at room temperature for 90 ps while structures generated as a fully stretched one are equilibrated at 600 K for 120 ps. The CCC-t and PLA helices are nearly destroyed from the beginning of equilibration. However, for both the HIV IN-LZM and the GCN4-p1 LZM structures, there is substantial helicity being retained throughout the entire course of equilibration. Although helix propagation profiles calculated indicate that both peptides possess about the same propensity to form an α-helix, the HIV IN-LZM helix appears to be more stable than the GCN4-p1 one as judged by a variety of analyses on both structures generated during the equilibration course. The fact that predicted HIV IN-LZM can exist as an α-helix is also supported by the results of high temperature equilibration run on the fully stretched structures generated. In this run, the RMS deviations between the backbone atoms of the structures with the lowest potential energy (PE) identified within every 2 ps and the structure with the lowest PE searched in the same course of simulation are calculated. For both the HIV IN-LZM and the GCN4-p1 LZM, these rms values decrease with the decrease of PE, which indicates that both structures are closer in conformations as their PEs are moved deeper into the PE well. © 1994 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360340806
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  • 6
    Electronic Resource
    Electronic Resource
    Surface excitation parameters of low-energy electrons crossing solid surfaces (1998)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 26 (1998), S. 682-688 
    Details
    ISSN: 0142-2421
    Keywords: surface ; surface excitation ; surface effect ; electron ; inelastic mean free path ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The surface excitation parameter, which describes the influence of surface excitations by electrons for the vacuum side in electron spectroscopies, has been calculated for electrons of 200-2000 eV energies crossing surfaces of Cu, Ag, Au, Fe, Pd, Ni, MgO and SiO2. These calculations were performed for both incident and escaping electrons by the use of dielectric response theory. Spatially varying differential inverse mean free paths for surface excitations as a function of electron distance from the surface were found. The results showed that small differences existed in the surface excitation parameter among different metals but large differences occurred between metals and semiconductors or insulators. Calculated surface excitation parameters were fitted very well to a simple formula, i.e. Ps=aE-b, where Ps is the surface excitation parameter and E is the electron energy. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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