ISSN:
1435-1463
Keywords:
Adrenoceptors
;
clonidine hypoactivity
;
developing brain
;
thyroid hormone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Clonidine-induced hypoactivity was studied in rats made neonatally hypo- and hyperthyroid (PTU or T4 administered between 1–27 days postnatally) as an indication of central presynapticα 2-adrenoceptor function. Paradoxically, at 28 days postnatally both treatments caused an increase in clonidine-hypoactivity compared with untreated control animals, which was not due to sex differences amongst littermates in the various groups. It is proposed that whereas the hyperthyroid neonate data perhaps reflect an enhancement of presynapticα 2 function similar to that seen in the adult rat brain, the result obtained for the hypothyroid neonates could perhaps be due to a retardation of the ontogeny of central noradrenergic neurones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01249101
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