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  • 1
    Electronic Resource
    Electronic Resource
    Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder (1991)
    Springer
    Psychopharmacology 105 (1991), S. 415-420 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT1A receptor ; Ipsapirone ; Fluoxetine ; Obsessive-compulsive disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fluoxetine (FLX) is a selective serotonin (5-HT) reuptake inhibitor with therapeutic benefit in patients with obsessive-compulsive disorder (OCD). To evaluate the effect of chronic FLX treatment on 5-HT1A receptor responsivity, hypothermic, neuroendocrine, and behavioral responses to the selective 5-HT1A receptor ligand ipsapirone (IPS) were examined in patients with primary OCD. A single dose of 0.3 mg/kg of IPS or placebo were given under double-blind, random-assignment conditions to ten patients before and during FLX treatment. The ability of IPS to induce hypothermia and ACTH/cortisol release was significantly attenuated during chronic FLX as compared to the pretreatment IPS challenge. The behavioral effects of IPS, though minimal, were less pronounced during FLX treatment. While FLX was effective in reducing the severity of OC symptoms, no significant correlation between attenuation of 5-HT1A receptor-mediated functional measures and FLX-induced improvement in OC symptoms was detected. These findings are consistent with the development of adaptive hyporesponsivity of the 5-HT1A receptor-effector system complex possibly involving subsensitivity of the 5-HT1A receptor itself and/or decreased functional activity of the postreceptor signal transduction. Modulation of 5-HT1A receptor-effector system function may be critical to the antidepressant/anti-OC efficacy of 5-HT reuptake inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244438
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  • 2
    Electronic Resource
    Electronic Resource
    5-HT1A receptor-effector system responsivity in panic disorder (1992)
    Springer
    Psychopharmacology 106 (1992), S. 111-117 
    Details
    ISSN: 1432-2072
    Keywords: 5-HT1A receptor ; Ipsapirone ; Hypothermia ; ACTH ; Cortisol ; Anxiety ; Panic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To explore 5-HT1A receptor responsivity in panic disorder (PD), hypothermic, neuroendocrine and behavioral responses to the selective partial 5-HT1A receptor agonist ipsapirone (IPS) were investigated in patients with primary PD and healthy controls. Fourteen patients and matched controls received a single oral dose of 0.3 mg/kg IPS or placebo under double-blind, random-assignment conditions. IPS induced hypothermia and corticotropin (ACTH)/cortisol release but had only minimal effects on behavior. Compared with controls, the patients with PD exhibited significantly attenuated thermoregulatory and neuroendocrine responses to IPS. Although the healthy subjects reported increased drowsiness and the PD patients rated themselves more nervous and less calm following administration of IPS, no consistent changes in ratings of anxiety or panic symptoms were recorded. The impaired hypothermic and ACTH/cortisol responses following 5-HT1A receptor activation reflects subsensitivity of both the pre- and post-synaptic 5-HT1A receptor-effector system, thus supporting the hypothesis that a 5-HT1A receptor-related serotonergic dysfunction may be linked to the pathophysiology of PD. Future studies of 5-HT1A receptor-effector complex function in conjunction with assessment of the responsivity of other subtypes (e.g. 5-HT2, 5-HT3) should promote the evaluation of 5-HT system integrity in anxiety disorders and its involvement in anxiolytic drug effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253597
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of sexual rest or sexual activity on the structure and function of the ventral prostate of the rat (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 212 (1985), S. 345-352 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Previous studies have shown that sexual activity increases the weight of the accessory sex glands significantly, while the organ weights correlate inversely with the assayable androgen receptor concentrations in the prostate of sexually active versus sexually resting rats. In an effort to determine the structural basis of this phenomenon, the ventral prostates of adult rats kept with female rats for 4-6 months (HE-rats) were compared to those kept in groups of 5 males in one cage (HO-rats) for the same period. As an estimate of the secretory function of the gland the concentration of prostatic binding protein (PBP) was determined in prostatic cytosols using a highly specific ELISA. Catecholamines were measured by means of HPLC and subsequent electrochemical detection. Morphological studies included immunocytochemistry of PBP, visualization of adrenergic nerves, stereological analysis of stromal and glandular compartments of the prostate, and electron microscopy of the epithelium.The main findings were as follows: (1) The prostates of HE-rats were 35% heavier than those of the HO-rats. (2) The content in secretion was in the same range in both HE-rats and HO-rats (1.5 and 1.44 mg PBP per 1 mg DNA). (3) Immunocytochemistry and electron microscopy demonstrated a very homogeneous secretion within the glandular lumen of HO-rats with a diminished amount of secretory material within the glandular cells.In HE-rats the glandular lumina were clearly larger in diameter and intraluminal secretion was less homogeneously stained. The height of the epithelium was increased and the individual secretory cells contained several secretory granules. Within the prostatic stroma the profiles of adrenergic nerves were more numerous in HE-rats, and a greater total amount of noradrenaline was present. At the fine structural level signs of enhanced membrane turnover, such as lysosomal structures, were prominent in prostatic epithelium of HE-rats, while in HO-rats mostly dense bodies were observed. The results indicate that sexual activity results in the functional adaption (activity hypertrophy) of the prostate as a result of nerve-associated control of glandular activity.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092120404
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A mammary-derived growth inhibitor (MDGI) related 70 kDa antigen identified in nuclei of mammary epithelial cells (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 138 (1989), S. 415-423 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The aim of the present study was to investigate the expression of the mammary derived growth inhibitor (MDGI) and the subcellular localization of MDGI related antigens in bovine mammary glands. Cell-free translation of poly (A+) = RNA, immunoprecipitation with rabbit anti-MDGI-antibodies, and estimation of the relative contents of MDGI by a radioimmunoassay in mammary tissue of different functional statess revealed that the 13 kDa MDGI was dramatically increased in terminally differentiated mammary tissue compared with the proliferating tissue from pregnant animals. To address the question of tissue localizationl, polyclonal anti-MDGI antibodies and antibodies directed aganist a sythetic peptide corresponding ot residues 69 to 78 of MDGI were used. Western blotting of tissue fractions revealed the cytosolic and microsomal localization of MDGI. Additionally, both types of antibodies a 70-kDa antigeninthe unclear fractionof differentiated mammary glands. Salt extraction and DNase I digestion of isolated unclei, as well as chromatin purification, indicated an association of the 70-kDa antigen with the chromatin. By means of the immunogold technique, MDGI-related antigens were localized within euchromatic unclear regions of epithelial cells in the intact differentiated mammary gland. The immunostaining was markedly diminished in the proliferating tissue. This finding raises the possibility that MDGI and the 70-kDa antigen influence cell proliferation by acting on geneexpression within the unclei of mammary glands.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041380225
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