ISSN:
1435-1463
Keywords:
Serotonin
;
sleep deprivation
;
recovery sleep
;
5-HT2 receptor
;
platelet 5-HT content
;
platelet density distribution
;
platelet IL-1β release
;
major depression
;
wakefulness
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Sleep deprivation (SD) represents a well-established therapy for major depression. Recent findings suggest that the antidepressive effects of sleep deprivation are mediated at least in part by pro-serotoninergic mechanisms. Furthermore, SD has been demonstrated to modify different host defense activities. We therefore investigated the serotonin (5-HT) content in platelets, platelet density distribution and 5-HT-induced IL-1β release from platelets in 10 healthy men before and after total SD (TSD) as well as after recovery sleep. Blood samples were drawn on 3 consecutive days at 7.00 h, 13.00 h, and 19.00 h, respectively. In addition, the psychophysiological parameters tiredness and wakefulness were assessed. After TSD the normal daily variation of IL-1β release with high morning levels and low evening levels was found to be significantly inverted. The release of IL-1β corresponded positively to the subjectively experienced tiredness of the probands. Analysis of platelet density distribution indicated a significant daily variation of low density platelets with low levels in the morning and high levels in the evening, which was absent after TSD. Our findings favour an increased pro-serotoninergic effect after TSD, which comprises respective variations of the host defense system, but is abolished by consecutive recovery sleep.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01273318
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