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  • 5-fluorouracil  (1)
  • Aortic baroreceptor afferents  (1)
  • Ash-free biomass  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Earthworm response to rotation and tillage in a Missouri claypan soil (1999)
    Springer
    Biology and fertility of soils 29 (1999), S. 343-347 
    Details
    ISSN: 1432-0789
    Keywords: Key words Aporrectodea trapezoides ; Diplocardia singularis ; Population density ; Ash-free biomass ; Crop rotation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  Agricultural management practices affect earthworm populations. A field experiment was conducted to determine the effect of two rotations and two tillage systems on earthworm population density and biomass in a claypan soil. The rotations were soybean/corn and wheat/corn, and the tillage systems were conventional tillage (chisel plowed and disked) and no-tillage. Earthworm and soil samples were collected in fall 1995, spring 1996, and fall 1996. Aporrectodea trapezoides and Diplocardia singularis were the species identified at the site. A. trapezoides accounted for 92–96% of the total earthworm population density and D. singularis accounted for only 4–8%. In a no-till system, soybean/corn rotation resulted in significantly greater population density of A. trapezoides compared with the wheat/corn rotation. Crop residue quality (low C:N ratio) and quantity were important factors in increasing A. trapezoides population density and biomass. Conventional tillage markedly decreased population density and biomass of both earthworm species. Our results suggest that rotation and tillage significantly affect earthworm population density and biomass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003740050563
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Presynaptic depolarization in myelinated vagal afferent fibres terminating in the nucleus of the tractus solitarius in the cat (1986)
    Springer
    Pflügers Archiv 406 (1986), S. 12-19 
    Details
    ISSN: 1432-2013
    Keywords: Slowly adapting lung stretch receptor afferents ; Aortic baroreceptor afferents ; Presynaptic depolarization ; Neural control of respiration ; Neural control of circulation ; Nuclei of the solitary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The presynaptic influences that act on terminals of slowly adapting lung stretch receptor afferents and aortic baroreceptor afferents within the nucleus of the solitary tract were assessed using intracellular recording and antidromic stimulation techniques. Central respiratory influences on the axcitability of lung stretch receptor terminals were observed in 29% (4 of 14) of measurements. These were confirmed in intracellular recordings where membrane depolarizations in synchrony with phrenic nerve discharge were seen in 17% (4 of 24) of fibres. In three cases membrane depolarization also occurred synchronously with artificial lung inflation. Neither tests of excitability nor intracellular recording revealed any evidence for equivalent presynaptic influences on 16 myelinated aortic baroreceptor terminals. Stimulation of the superior laryngeal nerve evoked depolarizations in 50% (7 of 14) of lung stretch receptor terminals. These took the form of complex waves of depolarization with both short (3–8 ms) and long latency (27–35 ms) components. The amplitude of the long latency response increased during the period of phrenic nerve discharge, i.e. during “central inspiration”. These effects are discussed in relation to the central respiratory influences on both respiratory and cardiovascular reflexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582946
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A phase I study of gemcitabine, 5-fluorouracil and leucovorin in patients with advanced, recurrent, and/or metastatic solid tumors (1998)
    Springer
    Investigational new drugs 16 (1998), S. 325-330 
    Details
    ISSN: 1573-0646
    Keywords: gemcitabine ; 5-fluorouracil ; leucovorin ; phase I study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Introduction: This was a dose escalation phase I trial designed to establish the MTD (maximum tolerated dose) and toxicity profile of the combination of gemcitabine, leucovorin and 5-fluorouracil (5-FU). Methods: Standard eligibility criteria were required for patients with advanced malignancy to enrol. Gemcitabine was escalated from an initial dose of 800 mg/m2. Gemcitabine was administered prior to leucovorin (25 mg/m2) followed by bolus 5-FU (600 mg/m2) every week for 3 weeks followed by 1 week of rest. Results: Of 21 patients enrolled, 20 were eligible for MTD determination. Patients received a median of three 4-week cycles of chemotherapy (range: 1 to 8 cycles). Toxicity was predominantly hematologic or gastroenterologic. Four dose levels were studied. At a gemcitabine dose of 1,500 mg/m2 systemic symptoms of fatigue accompanied hematologic toxicity and patients refused further therapy. At 1,250 mg/m2, full dose intensity was not delivered during the first cycle in 7 of 8 patients treated. Therefore, 1,000 mg/m2 was established as the recommended phase II dose for gemcitabine in this study. Antitumor activity was seen at all dose levels. Conclusions: The combination of gemcitabine, leucovorin and 5-FU was tolerable at full doses of all 3 drugs with an expected toxicity profile. Recommended phase II dose for gemcitabine was 1,000 mg/m2. Initial evidence of clinical activity was seen in a variety of tumor types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006242005837
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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