ISSN:
1573-8221
Keywords:
catecholamines
;
adrenals
;
5-fluorouracil
;
immobilization stress
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experiments on mice show that primary decrease in the catecholamine content in the adrenals 6 h and 1–2, and 4 days after immobilization stress is followed by catecholamine accumulation in the adrenal medulla. Practically the same dynamics within days 1–4 is observed after administration of a high dose of 5-fluorouracil; however, the restoration of the initial catecholamine level in mice treated with the cytostatic takes more than in stressed animals. These data suggests that high doses of 5-fluorouracil induce nonspecific activation of the sympathoadrenal system, presumably leading to adaptation to cytotoxic effects of 5-fluorouracil.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445417
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