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Twenty-four hour profiles of plasma C-peptide in Type 1 (insulin-dependent) diabetic children (1982)

Werther, G. A. ; Turner, R. C. ; Jenkins, P. A. ; [et al.]

Springer

Diabetologia 22 (1982), S. 245-249

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ISSN: 1432-0428

Keywords: Type 1 diabetes ; diabetic children ; blood glucose profiles ; insulin ; C-peptide ; B cell

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Twenty-four hour profiles of plasma C-peptide an index of endogenous insulin secretion, were performed in 15 Type 1 (insulin-dependent) diabetic children. Plasma C-peptide was detectable in six children, of whom four (‘C-peptide producers’) had peak values above normal fasting levels. In each of the six children with residual B cell function, there was a close correlation between plasma C-peptide and simultaneous blood glucose (r〉 0.50, p〈 0.05). Post-breakfast peak blood glucose was 10.2 ± 1.7 mmol/l (mean ±SEM) in the ‘C-peptide producers’ and 18.7 ± 1.7 mmol/l in the 11 children with low or no detectable C-peptide. Mean M-value, an index of deviation from an ideal blood glucose, was lower in the ‘C-peptide producers’ (p〈0.05). It is concluded that residual functioning B cells in diabetic children behave physiologically in that insulin secretion fluctuates in accordance with the prevailing blood glucose; and that the pattern of action of injected insulin is more critical in non-C-peptide producers who lack the post-prandial dampening effect provided by residual endogenous insulin secretion.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00281299

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A system for simultaneous exposure of small animals to 50-Hz electric and magnetic fields (1991)

Baum, J. W. ; Kuehner, A. V. ; Benz, R. D. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 12 (1991), S. 85-99

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ISSN: 0197-8462

Keywords: 60-Hz electric magnetic ; exposure apparatus ; rodents ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: Equipment designed for simultaneous exposure of rodents to 60-Hz electric and magnetic fields is described. Three identical systems were constructed, each capable of continuous exposure of 256 rats or 640 mice to a nominal electric field at 〈50 kV/m, and to horizontal and vertical magnetic fields at 〈 1 mT. Design features, construction details, and results of various tests of the systems are described. Tests were made: of phase relations between electric and magnetic fields; of uniformity of electric and magnetic fields; of changes across time in electric-field intensity as a result of animals' soiling of cages and various washing routines; of resistance of bedding material during humid and dry conditions; and of acoustic noise due to background, to field-generation equipment, and to air conditioning equipment. The results demonstrated that fields were effectively generated but that significant and troublesome changes in electric-field intensity occurred because of cage-soiling. However, when cages were frequently cleaned, field intensities were consistent from one exposure to another.

Additional Material: 9 Ill.