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  • 61.80.Mk  (1)
  • Aortic cell cultures  (1)
  • Cholestyramine  (1)
  • 1
    ISSN: 1432-2307
    Keywords: Nicotine ; Aortic cell cultures ; Cytoskeleton ; Computerized morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monolayers of endothelial, smooth muscle and fibroblastic cells of healthy porcine, bovine or human fetal origin were treated with 10−4 to 10−9 M final concentrations of nicotine. The effect was registered as changes in the synthesis and polimerization of the cytoskeleton. The silver and gold impregnation method produced anisotropy of the synthetic granules and of the final polymers of microtubules and filaments under physiological conditions as revealed by polarization microscopy. Since the orientation of the cells was inhomogenous in the cultures, the organization of the orientation was expressed as the sum of alternative diagonal and orthogonal measuring of anisotropy by a computerized microraster morphometry system joined to an OPTON cytophotometer. The 8-day-old control and treated cultures were also examined by electronmicroscopy. Nicotine stimulated the synthesis and polimerization of the cytoskeletal protein. This phenomenon is evident in smooth muscle cells, and partly also in endothelium. Fibroblasts were not influenced by the doses of nicotine tested.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 99-110 
    ISSN: 1432-1440
    Keywords: Hyperlipoproteinemia ; Atherosclerosis ; Hypolipidemic agents ; Cholestyramine ; Clofibrate ; D-thyroxine ; Nicotinic acid ; Sitosterol ; Hyperlipoproteinämie ; Arteriosklerose ; lipidsenkende Medikamente ; Cholestyramin ; Clofibrat ; D-Thyroxin ; Nicotinsäure ; Sitosterin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Cardiovasculäre Erkrankungen sind die Haupttodesursache in den westlichen Ländern. Es ist erwiesen, daß Erhöhungen der Serumlipide zur frühzeitigen Entstehung der Arteriosklerose beitragen. Mit der Klassifikation der Hyperlipoproteinämien entstand die Grundlage für gezielte diätetische und pharmakologische Behandlungskonzepte zur Senkung der Serumlipidkonzentrationen. Es werden die Ergebnisse medikamentöser und diätetischer Präventivstudien diskutiert und die Erkenntnisse über den Stoffwechsel der Lipoproteine sowie Wirkungsweise und Nebenwirkungen der gebräuchlichsten lipidsenkenden Medikamente dargestellt. Es ist zum gegenwärtigen Zeitpunkt berechtigt, Patienten mit besonderer Disposition zur frühzeitigen Arteriosklerose diätetisch und medikamentös zu behandeln.
    Notes: Summary Cardiovascular disease has become the major cause of death in the Western countries. There is strong evidence that elevations of serum lipids contribute to the pathogenesis of premature atherosclerosis. The classification of the hyperlipoproteinemias has been most beneficial as a guide to development of dietary and pharmacological regimens for lowering serum lipid concentrations. The results of dietary and drug prevention trials are discussed. Insight into the mechanisms involved in lipoprotein metabolism as well as the mode of action and of side-effects of hypolipidemic drugs is reviewed. Using present knowledge of heart disease research, it is reasonable to suggest dietary and drug treatments for the high risk patient.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 336 (1990), S. 353-356 
    ISSN: 1434-601X
    Keywords: 61.80.Mk ; 14.80.Pb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The rates forX ° creation by photons and electrons channeling along a crystal axis are estimated. The process is found to depend strongly on the parameters of the crystal fields. PromisingX ° production rates can therefore be obtained for germanium rather than for lighter elements.
    Type of Medium: Electronic Resource
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