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  • 1
    ISSN: 1432-0630
    Keywords: 71.25T ; 73.20
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Inverse photoemission spectra from Xe(111) crystals grown on an Ag(111) substrate show features which are interpreted in terms of density-of-states emission from the conduction bands of Xe along theГ-L direction. The energies of critical points determined by this method show good agreement with recent spin-polarised photoemission band mapping. A peak which is located in the fundamental band gap is tentatively assigned to surface emission, on the basis of an experiment in which this peak is quenched by covering the Xe crystal with one monolayer of krypton.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 451-457 
    ISSN: 1432-1440
    Keywords: β-Acetyldigoxin ; Digitoxin ; Nifedipine ; Pharmacokinetics ; Pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of nifedipine (N) on the pharmacokinetics and pharmacodynamics of β-acetyldigoxin (AD;n=11) and digitoxin (DGT;n=10) was studied in 21 patients with cardiac insufficiency stage II–III NYHA. Glycoside plasma concentration and renal excretion as well as electrocardiogram heart rate, atrioventricular transconduction time (PQ), duration of electrical systole corrected for heart rate (QTc), mean amplitude of T waves in leads V2 to V6 (TV2−6) and systolic time intervals total electromechanical systole index (QS2I), left ventricular ejection time index (LVETI), pre-ejection period index (PEPI), PEP/LVET-ratio were recorded repeatedly before and during coadministration of 40–60 mg/day N. Plasma AD concentrations were 0.64±0.22 ng/ml (mean±SD) before and 0.61±0.21 ng/ml during co-administration of N over 10–14 days, plasma DGT concentrations 13.9±4.1 ng/ml before and 13.7±4.5 ng/ml during co-administration of N over 4–6 weeks. Daily glycoside excretion was not affected by treatment with N. Heart rate and PQ-interval were not significantly changed during co-administration of N whereas T-wave flattening was intensified and QT-duration was lengthened. Concomitant treatment of AD and N led to an increase of PEPI and PEP/LVET compared to AD alone in ten patients whereas the systolic time intervals after concomitant treatment of DGT and N in most patients did not differ from those after DGT alone. From our findings we conclude that N had no clinically significant effect on pharmacokinetics and pharmacodynamics of AD or DGT.
    Type of Medium: Electronic Resource
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