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  • 1
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of mianserin in elderly depressed patients
    Amsterdam : Elsevier
    Psychiatry Research 8 (1983), S. 281-287 
    Details
    ISSN: 0165-1781
    Keywords: Mianserin ; age ; depressive illness ; pharmacokinetics
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1781(83)90016-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 583-586 
    Details
    ISSN: 1432-1041
    Keywords: tiapride ; Huntington's disease ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following durg administration with a mean value of 0.92 μg/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02455992
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: The effect of smoking (1981)
    Springer
    European journal of clinical pharmacology 21 (1981), S. 229-233 
    Details
    ISSN: 1432-1041
    Keywords: benzodiazepines ; clorazepate ; dipotassium clorazepate ; N-desmethyldiazepam ; pharmacokinetics ; smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of N-desmethyl-diazepam was evaluated after oral administration of clorazepate 20 mg to 12 healthy male volunteers (6 smokers; 6 non-smokers), aged 23–29 years. Plasma levels of desmethyldiazepam were measured by gas liquid chromatography. The half life of elimination (t1/2β) was significantly longer in the non-smoking volunteers than in the smokers: 54.7±17.7 versus 29.8±9.9 h (p〈0.05). Peak plasma concentrations (Cmax) were higher in non-smokers than in smokers, 413±106 µg/l and 245±50 µg/l, respectively (p〈0.05). The sedative effect of clorazepate was less severe in smokers than in non-smokers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627925
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of venlafaxine treatment on the behavioural and neurochemical changes in the olfactory bulbectomised rat (1998)
    Springer
    Psychopharmacology 136 (1998), S. 394-401 
    Details
    ISSN: 1432-2072
    Keywords: Key words Venlafaxine ; Olfactory bulbectomy ; β1-receptor binding ; 5-HT2 receptor binding ; 8-OH-DPAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study, the effect of chronic treatment with venlafaxine on β1 and 5-HT2 receptor populations was examined in the frontal cortex of olfactory bulbectomised (OB) and sham operated (SO) animals. The effect of these drugs on the behaviour of the animals on the elevated plus maze and the “open field” was also assessed. Removal of the bulbs resulted in a characteristic increase in locomotor activity in the OB animals in the “open field” which was reversed by chronic venlafaxine treatment. Venlafaxine produced a slight reduction in the number of open arm entries made by the OB animals although this failed to reach significance. Maximum change in temperature from baseline, following a single dose of 8-OH-DPAT (1.5 mg kg−1 SC), was used to assess the function of the 5-HT1A receptors. Chronic venlafaxine treatment had no effect on the hypothermic response to 8-OH-DPAT in the present study. A decrease in the affinity of β1-adrenoceptors was found following olfactory bulbectomy and this was normalised by treatment with venlafaxine. No bulbectomy-induced changes were evident 32 days post surgery in β1-adrenoceptor density; however, chronic treatment with venlafaxine significantly reduced the density of these receptors in the OB animals. Olfactory bulbectomy did not produce any changes in 5-HT2 receptor populations but venlafaxine administration significantly reduced the density of these receptors in both SO and OB animals. The findings of the present study further validate the usefulness of the OB as an animal model, for the detection of antidepressants from a wide variety of classes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050583
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    Paper (German National Licenses)
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