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Endothelin stimulates the release of prostacyclin from rat mesenteric arteries

Rakugi, H. ; Nakamaru, M. ; Tabuchi, Y. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 160 (1989), S. 924-928

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ISSN: 0006-291X

Keywords: ET; endothelin ; IND; indomethacin ; PG; prostaglandin ; PGI"2; prostacyclin ; pET; porcine endothelin ; rET; rat endothelin

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0006-291X(89)92523-0

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Endothelin stimulates the release of prostacyclin from rat mesenteric arteries

Rakugi, H. ; Nakamaru, M. ; Tabuchi, Y. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 160 (1989), S. 924-928

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ISSN: 0006-291X

Keywords: ET; endothelin ; IND; indomethacin ; PG; prostaglandin ; PGI"2; prostacyclin ; pET; porcine endothelin ; rET; rat endothelin

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/0006-291X(89)92523-0

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Endothelin inhibits renin release from isolated rat glomeruli

Rakugi, H. ; Nakamaru, M. ; Saito, H. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 155 (1988), S. 1244-1247

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ISSN: 0006-291X

Keywords: [abr] AMP; adenosin monophosphate ; [abr] AngI; angiotensin I ; [abr] EDTA.2Na; ethylenediaminetetraacetic acid, disodium salt ; [abr] ET; endothelin ; [abr] Isp; isoproterenol ; [abr] Nif; nifedipine

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(88)81273-7

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Endothelin inhibits renin release from isolated rat glomeruli

Rakugi, H. ; Nakamaru, M. ; Saito, H. ; [et al.]

Amsterdam : Elsevier

Biochemical and Biophysical Research Communications 155 (1988), S. 1244-1247

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ISSN: 0006-291X

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Physics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1016/S0006-291X(88)81273-7

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Effects of two angiotensin II analogues on blood pressure, plasma aldosterone concentration, plasma renin activity and creatinine clearance in normal subjects on different sodium intakes (1980)

Hata, T. ; Ogihara, T. ; Mikami, H. ; [et al.]

Springer

European journal of clinical pharmacology 18 (1980), S. 295-299

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ISSN: 1432-1041

Keywords: angiotensin II analogues ; aldosterone ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; dietics sodium ; plasma renin

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Two angiotensin II analogues (AIIA), 1-sarcosine, 8-isoleucine angiotensin II ([Sar1, Ile8]-AII) and 1-sarcosine, 8-alanine angiotensin II ([Sar1, Ala8-AII), were infused in six normal volunteers on high, regular and low sodium diets. The agonist and antagonist activities of these AIIA on blood pressure (BP), plasma aldosterone concentration (PAC), creatinine clearance and plasma renin activity were examined. Both AIIA had agonistic pressor activities in subjects on high and regular sodium diets, [Sar1, Ile8]-AII being more potent than [Sar1, Ala8]-AII. Both AIIA caused similar elevation of PAC in subjects on high and regular sodium diets, and an equally fall in PAC in subjects on a low sodium diet. Both AIIA strongly antagonized the rise in BP, the increase in PAC and the reduction of Ccr induced by AII administration in subjects on all three sodium diets. The results indicate that both AIIA can be used to examine the activity of the renin-angiotensin system in patients with hypertension, and they also suggest that AII interaction with its receptors differs in different target tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00561385

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Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]-and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects (1982)

Hata, T. ; Ogihara, T. ; Nakamaru, M. ; [et al.]

Springer

European journal of clinical pharmacology 23 (1982), S. 7-10

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ISSN: 1432-1041

Keywords: angiotensin II analogues ; angiotensin II receptors ; 1-sarcosine ; 8-threonine angiotensin II ; 1-sarcosine ; 8-isoleucine angiotensin II ; 1-sarcosine ; 8-alanine angiotensin II ; blood pressure ; plasma aldosterone concentration ; plasma renin activity

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The biological effects of 1-Sarcosine, 8-Threonine angiotensin II ([Sar1, Thr8]ANG II) on blood pressure, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were investigated in six normal subjects on an unrestricted diet, and compared with those of 1-Sarcosine, 8-Isoleucine ANG II ([Sar1, Ile8]ANG II) and 1-Sarcosine, 8-Alanine ANG II ([Sar1, Ala8]ANG II). All three ANG II analogues (A II A) showed agonistic pressor activity, that of [Sar1, Ile8]ANG II being greater than that of [Sar1, Thr8]ANG II or [Sar1, Ala8]ANG II. The antagonistic effect of [Sar1, Thr8]ANG II on blood pressure was less than [Sar1, Ile8]ANG II or [Sar1, Ala8]ANG II. Both [Sar1, Ile8]ANG II and [Sar1, Ala8]ANG II increased PAC and blocked the steroidogenic action of ANG II, while [Sar1, Thr8]ANG II showed little effect on PAC. All three A II A caused similar suppression of PRA and showed no inhibitory effect on the decrease in PRA produced by ANG II. These results indicate that [Sar1, Thr8] ANG II is an A II A with weak agonistic pressor action and that it has vascular selective properties. It is also suggested that ANG II receptors in a variety of target organs are heterogeneous.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01061369

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