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  • Concentric  (2)
  • clonidine  (2)
  • 8-hydroxy-2-(di-n-propylamino)tetralin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 69 (1987), S. 105-114 
    ISSN: 1435-1463
    Keywords: GH ; serotonin ; noradrenaline ; clonidine ; PCPA ; FLA-63 ; reserpine ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of the alpha2-adrenoceptor agonist clonidine induces growth hormone (GH) release in rat and man. In the present study it is shown that the GH response to clonidine is weaker in rats exposed to depletion of both noradrenaline and serotonin (by means of reserpine or the combined treatment of FLA-63 and PCPA) than in animals exposed to noradrenaline depletion (by means of FLA-63) only. The possibility that an impaired serotonergic neurotransmission contributes to the blunted GH responses to clonidine observed in patients suffering from endogenous depression is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 71 (1988), S. 99-113 
    ISSN: 1435-1463
    Keywords: Growth hormone ; sex steroids ; estrogens ; estradiol ; testosterone ; gonadectomy ; reserpine ; clonidine ; growth hormone releasing hormone (GHRH) ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of reserpine in a dose causing depletion of brain monoamines led to a complete suppression of the pulsatile secretory pattern of growth hormone (GH) in gonadectomized (GX) as well as in sham-operated male and female rats. In GX animals of both sexes treated with estradiol, but not in those treated with testosterone or dihydrotestosterone (DHT), the reserpine induced inhibition of GH release was partially antagonized. Administration of the alpha2-adrenoceptor agonist clonidine caused secretion of GH in reserpine pretreated, sham-operated rats. In GX male rats GH responses to clonidine were blunted, while in GX males treated with testosterone or estradiol, but not in those treated with DHT, the responses were restored. In female rats gonadectomy did not significantly affect the GH releasing effect of clonidine. However, administration of estradiol to GX females led to enhanced responses to the alpha2-agonist. Administration of the GH releasing hormone (GHRH) induced pronounced GH secretion in reserpine pretreated animals of both sexes; this effect was not significantly affected by gonadectomy. In GX males, however, GH responses to GHRH were enhanced by replacement with estradiol or testosterone, while in GX females, estradiol, but not testosterone, had the same effect.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 63 (1985), S. 297-313 
    ISSN: 1435-1463
    Keywords: Sex differences ; brain serotonin ; pargyline ; 8-hydroxy-2-(di-n-propylamino)tetralin ; body temperature ; 5-HT behavioural syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male and female rats were compared with respect to brain serotonin (5-HT) levels, synthetic capacity, receptor sensitivity, and CNS functions. Levels of whole brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) were higher in females. The accumulation of 5-HT after treatment with the monoamine oxidase inhibitor pargyline alone and in combination with the 5-HT precursor L-tryptophan was greater in females than in males. 5-HT increased and 5-HIAA decreased to the same extent in both sexes after administration of the 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). The temperature fall after all drug treatments was greater in females, but the “5-HT behavioural syndrome” was more pronounced in females merely after pargyline plus tryptophan; the behavioural response after 8-OH-DPAT did not differ between the sexes. These results are indicative of sex differences in the brain 5-HT neuronal systems. They are discussed in relation to differences between males and females in sexual behaviour, aggression and affective disorders.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1433-7347
    Keywords: Patellofemoral pain ; Taping ; Isokinetic ; Concentric ; Eccentric ; EMG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract The acute effect of patella taping on torque and electromyographic (EMG) activity in maximal voluntary concentric and eccentric action of the knee extensor and flexor muscles in patients with patellofemoral pain syndrome was studied in 48 patients (62 knees). The patients (28 female, 20 male) were tested concentrically and eccentrically on a Kin-Com dynamometer with simultaneous EMG recording with the patella untaped and medially or laterally taped. Patients with clinically normal patellar mobility did not improve their quadriceps performance by taping of the patella: after medial taping they decreased theur muscle torque during concentric work at 60°/s (P〈0.05) and eccentric work at 180°/s (P〈0.05). After lateral taping they decreased their muscle torque during concentric work at 60°/s (P〈0.01), and 180°/s (P〈0.05) and eccentric work at both 60°/s (P〈 0.01) and 180°/s (P〈 0.05). Moreover, these patients also decreased their agonist EMG activity during concentric work at 60°/s (P〈0.05) and 180°/s (P〈0.05) and their antagonist EMG activity during eccentric work at 60°/s (P〈0.01). Patients with a clinical lateral patellar hypermobility increased their knee extensor torque after medial taping at 60°/s during both eccentric work (P〈0.01) and concentric work (P〈0.05). The greatest improvement in quadriceps performance, however, was in patients with a clinical medial patellar hypermobility. They increased their knee extensor torque after lateral taping during eccentric work at both 60°/s (P〈0.001) and 180°/s (P〈0.001) and during concentric work at 60°/s (P〈0.001). They also increased agonist EMG activity during eccentric work at both 60°/s (P〈0.01) and 180°/s (P〈0.001) and during concentric work at 180°/s (P〈0.05). Patients with both lateral and medial patellar hypermobility increased their knee extensor torque by patellar taping in either direction; after medial taping there was an increase during eccentric work at both 60°/s (P〈0.01) and 180°/s (P〈0.05) and after lateral taping they also showed an increase during eccentric work at 60°/s (P〈0.01). There was a slight decrease in knee flexor torque with either medial or lateral taping in comparison with no taping. Furthermore, there was higher antagonist EMG activity during hamstring measurements when the patella was either medially or laterally taped as opposed to untaped. In all four groups of patients, except for the group with lateral and medial hypermobility, there was a highly significant correlation between patients' own evaluation of the taping and their patellar mobility according to the clinical examination.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Knee surgery, sports traumatology, arthroscopy 1 (1993), S. 162-168 
    ISSN: 1433-7347
    Keywords: Patello-femoral pain ; Isokinetic ; Concentric ; Eccentric ; Training
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract The aims of the present investigation were (a) to evaluate the effect of eccentric quadriceps training in patients with unilateral patellofemoral pain and (b) to compare the effect of eccentric and concentric quadriceps training in patients with bilateral patellofemoral pain. Fifteen patients (9 male and 6 female, aged 17–36 years with a mean of 27.5 years) participated in this study. Nine patients had unilateral pain and trained their painful leg eccentrically, while six had bilateral pain and trained one leg eccentrically and the other concentrically. Quadriceps muscle training was performed on a Kin-Com dynamometer at 90°/s and 120°/s angular velocity twice a week for 8 weeks. Before and after the treatment period the thigh muscle torques were measured on the Kin-Com dynamometer at 60°/s, 90°/s, 120°/s and 180°/s for quadriceps and at 60°/s and 180°/s for hamstrings. Nine controls, matched for gender and age with the group with unilateral pain, were tested in the same way on the Kin-Com dynamometer. For functional evaluation a knee score was calculated before training, after 8 weeks of training and at a mean of 3.4 years after completion of the training. After 8 weeks of training and at follow-up times of 1 and 3.4 years the patients were also questioned regarding whether or not they felt improvement from the training programme. To determine the degree of knee pain during the training Borg's pain scale was used. The results showed that, compared with the controls, the patients had a significantly lower knee extensor torque in their painful leg at all velocities measured. The greatest difference was found during eccentric actions. However, in comparison with the controls there were no significant differences in eccent ic and concentric knee flexor torques. After training there was a significant increase particularly in eccentric but also in concentric torque of the knee extensor in the painful leg of the eccentrically trained group. Of the six patients in the bilateral training group there were five who increased their concentric knee extensor torque and three who increased their eccentric torque. There were no significant differences in concentric and eccentric knee flexor torques before and after training in either of the legs in both training groups. The hamstring/quadriceps ratio was significantly higher in the patients' painful leg before training. However, due to increased quadriceps strength the hamstring/quadriceps ratio dropped after training. Patients in both groups reported no pain or mild pain during the training sessions. The eccentrically trained group was significantly improved both after 8 weeks of treatment and at follow-up 3.4 years later as evaluated using the knee score. The bilaterally trained group was significantly improved 3.4 years after completion of the training programme as evaluated using the knee score.
    Type of Medium: Electronic Resource
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