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  • 86Rb-erythrocyte assay  (1)
  • dipotassiumchlorazepate  (1)
  • stabilityin vitro  (1)
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Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    In vitro stability of proscillaridin A (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 135-139 
    Details
    ISSN: 1432-1041
    Keywords: Proscillaridin A ; digoxin ; 86Rb-assay ; stabilityin vitro ; gastric juice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In anin vitro study, proscillardin A was found to be rapidly inactivated at low pH. More than 50 per cent of its activity, measured by86Rb assay, was lost after incubation for 15 minutes at pH 1 and 37° C. Compared with proscillaridin, the rate of inactivation of digoxin was lower in these experiments. The rapid inactivation of proscillaridin might be of clinical importance when treating patients with this glycoside.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561563
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the pharmacokinetics of proscillaridin A in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 421-425 
    Details
    ISSN: 1432-1041
    Keywords: Proscillaridin ; enteric-coated tablets ; plasma levels ; urine excretion ; 86Rb-erythrocyte assay ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentration of proscillaridin was measured by a modified86Rd method during treatment with multiple doses of a commercial preparation of proscillaridin. Despite high doses, very low plasma levels were found, and there were only minute amounts of glycoside activity in urine and faeces. Administration of an enteric-coated proscillaridin preparation gave higher plasma levels, which raises the possibility of inactivation of the glycoside by acid gastric juice. The results suggest that proscillaridin has low biological availability when given orally, and that it is extensively metabolised in the body.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562316
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Intramuscular bioavailability of chlorazepate as compared to diazepam (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 229-230 
    Details
    ISSN: 1432-1041
    Keywords: diazepam ; dipotassiumchlorazepate ; benzodiazepines ; bioavailability ; administration ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Dipotassium chlorazepate (DPC) and diazepam (DZM) were given i.m. and i.v. to 6 healthy volunteers in doses of 20 mg (48.9 µmol) DPC and 15 mg (52.0 µmol) DZM. The interval between the injections was at least 1 week. Plasma samples were analyzed for DPC and DZM by HPLC. The bioavailability of DPC and DZM after i.m. administration, determined from computer calculated AUCs, was 1.04 and 0.85, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609698
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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