ISSN:
1432-0878
Keywords:
Hepatocytes
;
A CoA Carboxylase
;
Clofibrate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Cytochemical localization techniques and electron microscopy were used to evaluate the effects of clofibrate on acetyl-CoA carboxylase activity. It was demonstrated that the drug inhibited the activity of acetyl-CoA carboxylase in rat hepatocytes. Although the results in one of these experiments were somewhat variable, it is suggested that the inhibition of acetyl-CoA carboxylase may be the mechanism by which clofibrate exerts its hypolipidemic effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00431290
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