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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 95 (1988), S. 34-39 
    ISSN: 0942-0940
    Keywords: Extra-intracranial bypass surgery ; haemodynamic aspects ; angiographic findings ; ultrasound flow measurement ; Mavis Bloodflow Computer ; Toronto Bypass Study ; indications for bypass surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Angiographic and flow measurement results in 18 cases, who underwent extra-intracranial bypass surgery, are presented. The method was the Mavis® ultrasound technique. Main result:Patients with unilateral internal carotid artery (ICA) occlusion and additional contralateral ICA stenosis or occlusion had a permanent cerebral blood flow (CBF) increase as a consequence of the anastomosis. On the contrary, patients without contralateral flow impairment or with good spontaneous extra-intracranial anastomosis did not have a real CBF improvement but only a temporary flow increase on the anastomotic side with comparable flow decrease in the contralateral ICA. The so-called Toronto Bypass Study was designed to evaluate the effectiveness of extra-intracranial bypass surgery for stroke prevention but it did not prove its effectiveness in this regard. Intentionally it did not put or answer the question of possible haemodynamic benefit for special subgroups of patients with cerebrovascular occlusive disease. Our results suggest such a haemodynamic benefit, and in consequence an indication for bypass treatment may be given in cases with ICA occlusion and additional contralateral flow impairment and without sufficient spontaneous collateralization. The question of a stroke preventing effect in this special subgroup should be answered by another controlled study. But this will be almost impossible to realize because—as a consequence of the Toronto study—at least in our country almost no further patients are transferred to the neurosurgeon for possible bypass surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 52 (1980), S. 281-288 
    ISSN: 0942-0940
    Keywords: Spinal elastance ; narrow cervical spinal canal ; spondylogenic myelopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spinal elastance and the time course of pressure decrease after saline injection into the lumbar subarachnoid space was measured in a control group and in a group of patients with spondylogenic narrowing of the cervical spinal canal. The elastance is higher with retroflexion of the head than with anteflexion. This is more pronounced in degenerative diseases of the spine, proving the existence of a pincers mechanism. High elastance values at high volume changes indicate a narrowing of the cervical spinal canal. With a normal spinal canal the pressure decrease shows a slow monoexponential slope (T/2=100.8±13.4 seconds). In patients with partial obstruction of the spinal canal, especially with retroflexion of the head, a secondary pressure increase after termination of the volume injection was observed. This secondary pressure increase decreases in a biexponential manner with a fast slope (T/2=37.62±15.88 seconds) followed by a slow slope. With severe obstructions a plateau remained. This easily performed and well-tolerated measurement can be of aid in the quantification of obstructions of the spinal subarachnoid space.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 85 (1987), S. 128-137 
    ISSN: 0942-0940
    Keywords: ACNU ; BCNU ; intracarotid infusion ; malignant glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty patients with malignant gliomas were treated by operation, radiotherapy and additional intracarotid infusions of ACNU and BCNU. Positive results were obtained in the treatement of oligodendrogliomas and astrocytomas grade III and IV. On the contrary, the results in cases of glioblastoma multiforme were disappointing: neither survival time nor quality of life had been significantly improved. The protective effect of phenobarbitone against systemic toxicity by ACNU was not always confirmed in this study. Based on literature reports and our own experience the indications, technical aspects, unexpected complications and results of this therapeutic approach are discussed.
    Type of Medium: Electronic Resource
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