ISSN:
1573-2568
Keywords:
VASCULAR ENDOTHELIAL GROWTH FACTOR
;
ACUTE HEPATITIS
;
FULMINANT HEPATITIS
;
VARIOUS LIVER DISEASES
;
HEPATOCYTE GROWTH FACTOR
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The clinical significance of circulatingvascular endothelial growth factor (VEGF) in patientswith various liver diseases was investigated. Twenty-onepatients with acute hepatitis (AH), 40 with chronic hepatitis (CH), 34 with cirrhosis (LC), 16 withfulminant hepatitis (FH), 10 with primary biliarycirrhosis (PBC), 12 with autoimmune hepatitis (AIH), and120 healthy individuals were included. Serum VEGF levels were measured by a chemiluminescenceenzyme-linked immunosorbent assay. The mean values ofserum VEGF levels in the patients with AH, CH, LC, FH,AIH, PBC, and control were 172.7, 58.0, 44.1, 37.3, 49.7, 74.9, and 65.0 pg/ml, respectively. Thepatients with AH had a level of serum VEGF significantlyhigher than that of the control group (P 〈 0.001).The serum VEGF levels in survivors of FH weresignificantly increased, but not in the nonsurvivors in therecovery phase compared with the levels on admission (P〈 0.05). In the LC patients, serum VEGF levels weresignificantly lower than those of the control group (P 〈 0.05). These findings suggest thatserum VEGF level may be associated with hepatocyteregeneration grade.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018863718430
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