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  • AFLP  (1)
  • Aplastic anaemia  (1)
  • Barley  (1)
  • Bone marrow culture  (1)
  • 1
    Electronic Resource
    Electronic Resource
    CFU-C inhibitors in aplastic anaemia (1984)
    Springer
    Annals of hematology 48 (1984), S. 61-74 
    Details
    ISSN: 1432-0584
    Keywords: Aplastic anaemia ; CFU-C ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral blood lymphocytes from 15 patients with marrow aplasia were tested for their ability to inhibit the proliferation of normal granulopoietic precursor cells (CFU-C) in agar culture, relative to the inhibitory effect of normal lymphocytes studied in parallel. Eight of the 15 patients with marrow aplasia had lymphocytes which were significantly less inhibitory to normal CFU-C than controls whereas 3 patients had lymphocytes which were significantly more inhibitory. Two further patients who had recovered from marrow aplasia were also studied. The effect of patient's plasma and normal plasma on normal CFU-C proliferation was also studied and in 1 case a potent inhibitor of granulopoiesis was demonstrated. In 9 cases CFU-C could be cultured from patient's marrow, and parallel studies examining the effects of lymphocytes or plasma on patient's CFU-C. In none of the 9 marrow samples tested was inhibition by patient lymphocytes significantly greater than normal controls. The results highlight the heterogeneity inherent in the study of aplastic states and serve to underline the importance of controls. In only a minority of cases (20%) was lymphocyte suppression of normal granulopoiesis by lymphocytes from patients with aplastic anaemia significantly greater than normal lymphocyte suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320032
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Steroid responsive cyclical neutropenia (1984)
    Springer
    Annals of hematology 48 (1984), S. 153-159 
    Details
    ISSN: 1432-0584
    Keywords: Cyclical neutropenia ; Prednisolone ; Remission ; Bone marrow culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 19-year old girl with severe cyclical neutropenia associated with life-threatening infection and who responded dramatically to the administration of oral prednisolone is described. During reduction and eventual cessation of steroid therapy normal or near normal neutrophil counts have been maintained, and there has been parallel improvement in clinical well-being. Prior to therapy and at a time of peak blood neutrophil count low numbers of granulocyte-macrophage progenitor cells (CFU-C) were found in the patient's bone marrow, and her lymphocytes co-cultured with normal marrow failed to show the inhibitory effect normally seen with normal lymphocytes. The findings in this patient are compared with those in the two other cases where cyclical neutropenia has been shown to respond to steroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320338
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Introgression of quantitative trait loci (QTLs) determining stripe rust resistance in barley: an example of marker-assisted line development (1998)
    Springer
    Theoretical and applied genetics 96 (1998), S. 123-131 
    Details
    ISSN: 1432-2242
    Keywords: Key words QTL ; AFLP ; Marker-assisted selection ; Barley ; Puccinia striiformis f.sp. hordei
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Genome-analysis tools are useful for dissecting complex phenotypes and manipulating determinants of these phenotypes in breeding programs. Quantitative trait locus (QTL)-analysis tools were used to map QTLs conferring adult plant resistance to stripe rust (caused by Puccinia striiformis f.sp. hordei) in barley. The resistance QTLs were introgressed into a genetic background unrelated to the mapping population with one cycle of marker-assisted backcrossing. Doubled-haploid lines were derived from selected backcross lines, phenotyped for stripe-rust resistance, and genotyped with an array of molecular markers. The resistance QTLs that were introgressed were significant determinants of resistance in the new genetic background. Additional resistance QTLs were also detected. The susceptible parent contributed resistance alleles at two of these new QTLs. We hypothesize that favorable alleles were fixed at these new QTLs in the original mapping population. Genetic background may, therefore, have an important role in QTL-transfer experiments. A breeding system is described that integrates single-copy and multiplex markers with confirmation of the target phenotype in doubled-haploid lines phenotyped in field tests. This approach may be useful for simultaneously producing agronomically useful germplasm and contributing to an understanding of quantitatively inherited traits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050718
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    Paper (German National Licenses)
    Fulltext
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