ISSN:
1432-1335
Schlagwort(e):
Intestinal Tumors
;
DMH
;
ALG
;
Metastases
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The induction of intestinal tumors by weekly subcutaneous administration of DMH and their metastatic spread, were studied in rats treated with or without ALG. Early morphologic changes of the intestinal mucosa were examined, as well as the influence of ALG on tumor induction, tumor growth, and mode of metastasis. Whether treated with ALG or not, the intestinal mucosa showed 1. glandular hyperplasia with goblet cell depletion and elongation of the germinative zone (weeks 5–13) 2. glandular atrophy intermingled with hyperplasia (week 13) 3. induction of neoplastic micro-lesions (week 17) 4. production of macroscopic tumors (week 21). Tumor induction was negative in 14% of rats (5/37) at the last autopsy after 33 weeks. Particular attention was given to the morphologic changes of the mucosa over lymph follicles which was a frequent site of origin for neoplastic lesions. In this study, ALG treatment failed to enhance tumor induction or tumor growth. It was ascertained, however, that ALG treatment significantly favors tumor spread by dissemination and conglomerate formation.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00284091
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