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  • 1
    Electronic Resource
    Electronic Resource
    Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus (1997)
    Springer
    Diabetologia 40 (1997), S. 256-261 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Amylin ; hypertension ; calcitonin ; ACE inhibition ; calcitonin gene related peptide.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amylin (or islet amyloid polypeptide) has been reported to have binding sites in the central nervous system and the kidney and has been shown to activate plasma renin. It has been postulated that this peptide may be an important mechanistic link between hypertension and diabetes in the insulin resistance syndrome. To explore this issue, the effects of rat amylin on mean arterial blood pressure were investigated in anaesthetised rats. Amylin elicited a pressor response of approximately 10 mmHg (maximal at 100 pmol · kg–1) which was apparent within 30–60 s and persisted over 15 min. At higher concentrations amylin elicited a hypotensive response (negative log IC50 8.52 mol · kg–1). The novel amylin receptor antagonist AC413 (12 nmol · kg–1· min–1) reduced the pressor response but not the hypotensive effects of amylin. The peptide antagonist calcitonin gene-related peptide (CGRP)8–37 (12 nmol · kg–1· min–1) reduced the pressor response elicited by amylin and also antagonized the hypotensive effect of amylin. Pre-treatment of animals with the ganglion blocker mecamylamine (3 mg · kg–1 s. c.) reduced the pressor effect of amylin. Following the administration of the angiotensin converting enzyme inhibitor ramiprilat (300 nmol · kg–1 i. v.) the pressor response to amylin was reduced. Salmon calcitonin also elevated blood pressure in the anaesthetised rat; doses of amylin and salmon calcitonin associated with a pressor effect were associated with increases in plasma renin activity. We conclude that amylin may act centrally to elevate blood pressure in the anaesthetised rat, possibly through activation of the renin angiotensin system. [Diabetologia (1997) 40: 256–261]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050672
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of Alumina Scales Formed During Isothermal and Cyclic Oxidation of Plasma-Sprayed TBC Systems at 1150°C (1999)
    Springer
    Oxidation of metals 52 (1999), S. 31-76 
    Details
    ISSN: 1573-4889
    Keywords: SCALE FRACTURE ; OXIDE SCALES ; ALUMINA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The isothermal- and cyclic-oxidation behavior ofthermal barrier coating (TBC) systems consisting ofvacuum plasma-sprayed (VPS) Ni-22Cr-10Al-1Y (wt.%) bondcoatings and air plasma-sprayed (APS)Y2O3-stabilized ZrO2 (YSZ) top coatings (onsingle-crystal superalloys) was investigated. Themicrostructures, flaw contents, and fracture behavior ofthe Al2O3 scales formed duringoxidation testing at 1150°C were characterized (by analysis of coating andscale fracture surfaces and metallographic crosssections). Significant localized fracture and bucklingof the Al2O3 scales that formedalong the bond-coat-top-coat interfaces were observed after cyclic oxidationof TBCs. However, substantial amounts of localized scaledamage did not induce rapid TBC failure. Decohesion ofthe columnar alumina scales on the rough bond-coat surfaces occurred by both internalAl2O3 fracture (parallel to themetal surface) and oxide-metal delamination. There weremicrostructural indications ofAl2O3 scale crack healing bysintering into planar arrays of voids. Alumina scales that formed onconvex NiCrAlY surfaces (with radii of 50 μm or less)often contained significant amounts of internal voids(along grain boundaries) after cyclic oxidation, whereas scales formed by isothermal oxidationcontained few visible voids. Accelerated void growth inAl2O3 scales on the irregularNiCrAlY surfaces appeared to be creep-related and wasattributed to the synergistic effects of geometric and thermalstresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018870923397
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    Paper (German National Licenses)
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