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  • 1
    Electronic Resource
    Electronic Resource
    Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage (1990)
    Springer
    Acta neurochirurgica 107 (1990), S. 11-15 
    Details
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; chronic cerebral vasospasm ; calcium antagonist ; AT877 ; HA 1077
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The initial dose-escalating clinical trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage is reported. AT877 is characterized by its strong spasmolytic activity, its inhibition of intracellular calcium ion activity, and the inhibiton of several protein kinases. A total of 113 patients (Hunt and Hess grades I to IV) who had undergone surgery within 3 days of aneurysmal rupture entered the study. Patients were divided into 5 groups according to the total daily dose of AT877: I: 20 mg; II: 40 mg; III: 60 mg; IV: 90 mg; and V: 120–180 mg. AT877 was given by intravenous infusion over 30 min two or three times a day for 14 days after surgery. Although AT877 did not completely abolish angiographic vasospasm, severe vasospasm was seen less frequently in patients given higher doses. Vasospasm was the cause of a poor clinical outcome (Glasgow outcome scale rating 3 or greater) in 19%, 7%, 9%, 8%, and 6% of the patients in groups I to V, respectively. The results indicated a favourable clinical effect of AT877 at doses above 40 mg per day. Only mild hypotension was seen, even when 60 mg of AT877 was infused over 30 min. AT877 appears to be effective in patients with subarachnoid haemorrhage. Part of its effect may be attributable to protection of the brain from ischaemic insults due to chronic cerebral vasospasm. However, the drug still needs to be evaluated in a placebo-controlled double-blind trial (which is currently being carried out).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402606
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  • 2
    Electronic Resource
    Electronic Resource
    Insulin binds to specific receptors and stimulates macromolecular synthesis in C 6 glioma cells (1988)
    Springer
    Acta neurochirurgica 93 (1988), S. 10-12 
    Details
    ISSN: 0942-0940
    Keywords: Insulin receptors ; glioma cells ; DNA synthesis ; RNA synthesis ; protein synthesis ; 3H-thymidine ; 3H-uridine ; 3H-leucine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The existence of insulin receptors and biological responces to insulin on macromolecular synthesis have been studied in C6 glioma cells. Binding of125I-insulin to C6 glioma cells was specific, time-and PH-dependent. Porcine insulin competed for1125I-insulin binding in a dose-dependent manner. Unlabeled polypeptides, including glucagon, bovine growth hormone, bovine prolactin did not compete for125I-insulin binding. Scatchard analysis of the binding data gave a curvilinear plot which may indicate negative co-operativity or the existence of both high and low affinity (Ka=7.55 × 1010 −4.25 × 109) sites. Incubation of cultures with insulin caused a time and dose-dependent stimulation of DNA, RNA and protein synthesis in C 6 glioma cells (measured by3H-thymidine,3H-uridine or3H-leucine incorporation into DNA, RNA, or protein respectively). The increase of macromolecular synthesis was admitted at more than 2 nM concentration of insulin. Maximal stimulation of DNA synthesis (142% of control) occurred 6 hours after incubation with 167 nM insulin. The same concentration of insulin caused a 45% increase in 1 hour on RNA synthesis, a 37% increase in 2 hour on protein synthesis. These results indicate that C 6 glioma cells have specific insulin receptors capable of mediating effects of insulin on macromolecular synthesis. Insulin in the brain and even blood may be an important growth factor in the glioma cells of the patients with disrupted bloodbrain-barrier.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409895
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  • 3
    Electronic Resource
    Electronic Resource
    Radical-induced ionic polymerization in the presence of maleic anhydride. II. Cationic polymerization of 1,2-butylene oxide by benzoyl peroxide and α,α′-azobisisobutyronitrile in the presence of maleic anhydride (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 3653-3660 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The cationic polymerization of 1,2-butylene oxide initiated by radical catalysts has been investigated in detail in the presence of maleic anhydride. The active species of this ionic polymerization was thought to be a conjugated radical of poly(maleic anhydride).
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070181212
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  • 4
    Electronic Resource
    Electronic Resource
    Radical-induced ionic polymerization in the presence of maleic anhydride. III. Polymerization of isobutyl vinyl ether initiated by trapped radicals in poly(maleic anhydride) (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 3661-3670 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: In a previous paper1 it was mentioned that trapped radicals in poly(maleic anhydride) (Poly-MAH) have the ability to initiate cationic polymerization. In this paper, the cationic polymerization of isobutyl vinyl ether (IBVE) is described using Poly-MAH as the initiator. These radicals show different behavior during polymerization depending upon their structure. In particular, large conjugated radicals initiate ionic polymerizations.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1974.070181213
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    Paper (German National Licenses)
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