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  • Amphetamine  (5)
  • Patch clamp  (5)
  • Abdomen  (3)
  • Dopamine  (3)
  • 1
    Electronic Resource
    Electronic Resource
    A syndrome of multiple gastrointestinal atresias with intraluminal calcification (1979)
    Springer
    Pediatric radiology 8 (1979), S. 227-231 
    Details
    ISSN: 1432-1998
    Keywords: Abdomen ; Calcification, bile ducts ; Biliary gas, gastrointestinal ; Atresias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An infant with multiple gastrointestinal atresias from the stomach to the rectum is reported and the literature concerning this syndrome is reviewed. The syndrome has been reported, to date, exclusively in infants born to families with a French-Canadian background. The radiological hallmark of this syndrome is extensive calcification of intraluminal content between the areas of atresia which appears as rounded or oval homogeneous radiopacities on abdominal radiographs. Inheritance is thought to be autosomal recessive and the etiology is uncertain. All previously reported cases have died. The significance of biliary gas, seen in postoperative films, is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00974040
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Congenital epithelial splenic cysts in children (1982)
    Springer
    Pediatric radiology 12 (1982), S. 119-125 
    Details
    ISSN: 1432-1998
    Keywords: Spleen ; Cysts ; Ultrasound ; Abdomen ; Mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical, radiographic and sonographic features of four children with congenital epithelial splenic cysts are described. All four cases presented with a left upper quadrant mass and few symptoms. In one case the spleen descended into the pelvis in the upright position. In three cases the sonographic findings showed the mass to be completely sonolucent. In the fourth case the mass was echogenic and echoes were distributed homogeneously throughout the mass. These internal echoes were due to the presence of fat droplets within the cyst fluid. Internal echoes may also be due to hemorrhage into the cyst. In all four cases a rim of splenic tissue was visible around part of the cyst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00971799
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Unusual renal distortion and displacement due to the spleen (1982)
    Springer
    Pediatric radiology 12 (1982), S. 185-189 
    Details
    ISSN: 1432-1998
    Keywords: Abdomen ; Computed tomography ; Pseudomasses ; Kidney ; Displacements ; Distortions ; Spleen ; Lobulation ; Variants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Occasional normal anatomic variations may produce radiographic appearances that closely simulate disease and visceral enlargement may cause unusual displacements of adjacent organs. Two cases are reported in whom prominent splenic lobulation caused flattening of the upper pole of the left kidney. The appearance simulated that produced by a suprarenal mass. The value of CT in differentiating this normal variation from disease is discussed. A third patient in whom massive splenomegaly caused upward displacement of the left kidney is also reported. The literature concerning visceral relationships in the left upper quadrant and the normal variations that simulate disease is reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999308
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Nicotine as a discriminative cue in rats: Inability of related drugs to produce a nicotine-like cueing effect (1972)
    Springer
    Psychopharmacology 27 (1972), S. 379-387 
    Details
    ISSN: 1432-2072
    Keywords: Nicotine ; State-Dependent Behavior ; Lobeline ; Amphetamine ; Arecoline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to enter one arm of a T-maze after the subcutaneous administration of 0.4 mg/kg and to enter the opposite arm following the injection of an equal volume of saline. Administration of 0.4 mg/kg nicotine isomethonium iodide hydroiodide, 0.4–10.0 mg/kg lobeline sulfate, 2.0 and 4.0 mg/kg d-amphetamine sulfate and 0.25–2.0 mg/kg arecoline hydrobromide produced responses which resembled the established saline effect. Pretreatment with 10.0 mg/kg lobeline had no significant effect on the nicotine-cued response. The inability of these structurally and/or functionally similar drugs to produce a nicotine-like discriminative effect is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429392
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome (1976)
    Springer
    Psychopharmacology 49 (1976), S. 191-195 
    Details
    ISSN: 1432-2072
    Keywords: Pilocarpine ; Atropine ; Dexetimide ; Methylscopolamine ; Morphine addiction ; Narcotic withdrawal ; Aggression ; Wet shakes ; Diarrhea ; Dopamine ; Acetylcholine interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both ‘wet-dog’ like body shakes and aggression but it increased diarrhea and weight loss. Pretreatment with atropine blocked all of the effects of pilocarpine on withdrawal signs. Methylscopolamine pretreatment blocked only diarrhea. The administration of atropine or dexetimide produced no significant effect on any of the withdrawal signs. These results indicate a role for central cholinergic mechanism in narcotic withdrawal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427289
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training (1990)
    Springer
    Psychopharmacology 102 (1990), S. 221-226 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Norfenfluramine ; Amphetamine ; Pentobarbital ; Session-to-criterion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245925
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats (1975)
    Springer
    Psychopharmacology 42 (1975), S. 185-193 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Dopamine ; Haloperidol ; State-Dependent Behavior ; Apomorphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-Β-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas α- and Β-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429551
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 399-405 
    Details
    ISSN: 1432-2013
    Keywords: Sodium channel ; Oocyte ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Na currents recorded from inside-out macropatches excised from Xenopus oocytes expressing the α subunit of the rat brain Na channel IIA show at least two distinguishable components in their inactivation time course, with time constants differing about tenfold (τ h1 = approx. 150 μs and τ h2 = approx. 2 ms). In excised patches, the inactivation properties of Na currents changed with time, favoring the faster inactivation kinetics. Analysis of the fast and slow current kinetics shows that only the relative magnitudes of τ h1 and τ h2 components are altered without significant changes in the time constants of activation or inactivation. In addition, voltage dependence of both activation and steady-state inactivation of Na currents are shifted to more negative potentials in patches with predominantly fast inactivation, although reversal potentials and valences remained unaltered. We conclude that the two inactivation modes discerned in this study are conferred by two states of Na channel the interconversion of which are regulated by an as yet unknown mechanism that seems to involve cytosolic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374253
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 406-413 
    Details
    ISSN: 1432-2013
    Keywords: Sodium channel ; Oocyte ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Macroscopic currents of wild-type rat brain IIA (RBIIA) and mutant Na channels were recorded in excised patches from Xenopus oocytes. A charge deletion (K859Q) and an adjacent conservative mutation (L860F) in the second domain S4 membrane-spanning region differentially altered voltage sensitivity and kinetics. Analysis of voltage dependence was confined to Na currents with fast inactivation kinetics, although RBIIA and K859Q (but not L860F) also showed proportional shifts between at least two gating modes, rendering currents with fast or slow inactivation kinetics, respectively. Compared to RBIIA, the midpoint of the activation curve was shifted in both K859Q and L860F by 22 mV to more positive potentials, yet this shift was not associated with a corresponding change in the voltage dependence of time constants for activation (τ a) or inactivation (τ h1, τ h2). L860F showed faster activation time constants τ a than RBIIA, while K859Q was slower for both the activation (τ a) and the inactivation components (τ h1). Similarly, the steady-state inactivation curve of L860F but not K859Q shifted by 9 mV in the hyperpolarizing direction. Thus, the fourth charge in the IIS4 transmembrane segment exerts control over voltage sensitivity and kinetics of activation and may interact with structure that influence other aspects of channel gating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374254
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  • 10
    Electronic Resource
    Electronic Resource
    A direct-reading device for measurement of patch-clamp micropipette tip diameters (1990)
    Springer
    Pflügers Archiv 417 (1990), S. 255-258 
    Details
    ISSN: 1432-2013
    Keywords: Micropipette ; Inner tip diameter ; Electronic device ; Patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper describes an electronic device for the measurement of the diameter of the tip opening of micropipettes. The device measures the threshold pressure required to produce bubbles from the micropipette submerged in a liquid and displays the tip inner diameter in micrometres. We demonstrate that this technique can be used effectively in a range of liquids of different density, surface tension and viscosity and that the thickness of the glass from which the micropipettes are made does not influence the measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370989
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    Paper (German National Licenses)
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