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  • Abdominal aortic aneurysm  (1)
  • Indication  (1)
  • Key words: Group B streptococci—Pulmonary surfactant—Oxygen radicals—Lipid peroxidation.  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Direct and Phagocyte-mediated Lipid Peroxidation of Lung Surfactant by Group B Streptococci (2000)
    Springer
    Lung 178 (2000), S. 317-329 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Group B streptococci—Pulmonary surfactant—Oxygen radicals—Lipid peroxidation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In newborn infants, group B streptococci (GBS) often cause pneumonia, with polymorphonuclear leukocytes (PMN) migrating into the lungs. Because surfactant therapy may be needed in such patients, we evaluated the interaction between GBS or GBS-stimulated PMN and a surfactant preparation (Curosurf) in vitro. The superoxide production of GBS strains or GBS-activated PMN was measured, using the nitroblue tetrazolium (NBT) test and the subsequent lipid peroxidation (LPO) as the content of malondialdehyde (MDA) and 4-hydroxyalkenals (4-HNE). The growth of GBS in surfactant was determined and related to the LPO. Finally, the effect of LPO on surfactant activity, caused by GBS-stimulated PMN, was assessed by measuring dynamic surface tension in a pulsating bubble surfactometer. Curosurf diminished the NBT reduction by both live GBS and GBS-stimulated PMN. Surfactant was peroxidized by reactive oxygen species (ROS) from both GBS and GBS-stimulated PMN in a time-dependent manner. Vitamin E significantly reduced the peroxidation level of surfactant in both cases. Surfactant peroxidation was associated with a reduction in the number of live bacteria. The biophysical activity of Curosurf was impaired by GBS-stimulated PMN, as reflected by increased minimum surface tension during cyclic compression. These findings indicate that Curosurf undergoes LPO by ROS produced by GBS and/or PMN. We speculate that exogenous surfactant preparations should be supplemented with vitamin E or another antioxidant, when given to infants with GBS pneumonia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004080000035
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    328. Das infrarenale Bauchaortenaneurysma (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 847-847 
    Details
    ISSN: 1435-2451
    Keywords: Abdominal aortic aneurysm ; Diagnosis ; Indication ; Operations ; Bauchaortenaneurysma ; Diagnose ; Indikation ; Operation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An der II. Chirurgischen Abteilung des AK Harburg wurden in 5 Jahren (1981–1985) 263 Patienten mit einem infrarenalen Bauchaortenaneurysma operiert. Im vorliegenden Film werden die Diagnostik beim Bauchaortenaneurysma, die Untersuchungstechnik und -taktik beim Hausarzt und in der Klinik vorgestellt sowie die Operation zweier Aneurysmen gezeigt. Postoperative Probleme, Risikofaktoren und Kontraindikationen zur Operation werden diskutiert.
    Notes: Summary At the 2nd Surgical Department of the Harburg General Hospital in Hamburg, Germany, 263 patients with infrarenal abdominal aortic aneurysms were operated on during a 5-year period from 1981 to 1985. The film demonstrates diagnostic procedures and evaluation techniques, as employed by the family physician and the clinician. Moreover, operations for two abdominal aneurysms are shown. Postoperative problems, risk factors, and contraindications against operative procedures are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274648
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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