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  • Chromosome 16  (2)
  • Abnormal marrow eosinophils  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acute eosinophilic leukemia: characterization by cytochemistry, chromosomal analysis, and in vitro colony formation (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 133-137 
    Details
    ISSN: 1432-1440
    Keywords: Eosinophilic leukemia ; Chromosome 16 ; Morphology ; Cytochemistry ; Colony-forming cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A pericentric inversion of chromosome 16 and acute myelomonocytic leukemia [AMMoL, M4 French-American-British (FAB)] with abnormal bone marrow eosinophils has recently been shown to form a new cytogenetic-clinicopathological entity. A patient otherwise undistinguishable from the more typical cases but lacking the FAB criteria for AMMoL is described. In such a situation, in vitro colony formation closely resembling that of acute myoblastic leukemia together with the clinical, morphological, cytochemical, and cytogenetic characteristics reported might serve as an indicator that these patients run an acute course justifying a diagnosis of acute eosinophilic leukemia and immediate institution of aggressive chemotherapy. The importance of the in vitro growth pattern regarding the differential diagnosis of disorders associated with predominant proliferation of eosinophils is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734251
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16 (1984)
    Springer
    Annals of hematology 48 (1984), S. 263-267 
    Details
    ISSN: 1432-0584
    Keywords: Leukemia, acute myelomonocytic ; Abnormal marrow eosinophils ; Chromosome 16
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogeneticmorphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosinophils (FAB M4), chloracetate esterase- and periodic acid-Schiffpositivity of eosinophilic granules, and pericentric inversion of chromosome 16, in this case combined with trisomy 8. So far 18 such cases have been reported from a single institution. The implications of this new association on the diagnosis of acute leukemia with abnormal eosinophils are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320396
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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