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  • polymorphism  (3)
  • Acetylator phenotype  (1)
  • IMV (Intermittent Mandatory Ventilation)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acetylator polymorphism in rheumatoid arthritis (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 279-281 
    Details
    ISSN: 1432-1041
    Keywords: Rheumatoid arthritis ; Acetylator phenotype ; polymorphism ; sulphamethazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetylator phenotype has been determined with sulphamethazine (sulphadimidine) in 69 Spanish patients with rheumatoid arthritis (48 females), all of whom were on second line therapy, and in 96 age-matched normal controls (54 females). Thirty-two patients (46.4%) and 56 controls (58.3%) were classified as slow acetylators. On analysing separately the females in both groups, 37.5% of patients and 63% of controls were found to be slow acetylators. No difference was found in the males (patients 66.3% and controls 52.4% slow acetylators). Rapid acetylator phenotype may be a risk factor for the development of severe rheumatoid arthritis in women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315397
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Frequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 593-595 
    Details
    ISSN: 1432-1041
    Keywords: Mephenytoin ; Pharmacogenetics ; polymorphism ; drug metabolism ; phenotype ; caucasian
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, healthy Spanish Caucasian subjects, based on the enantiomeric S/R mephenytoin ratio in urine collected 0–8 h and 24–32 h after intake of the racemic drug. Five of the subjects were PM (1.34%, 95% confidence interval 0.18–2.59%), a prevalence lower than in 6 other Caucasian populations, but only significantly lower than in studies in France and Switzerland (P〈0.01). We suggest that this difference might be due to the use of different phenotyping procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02440867
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Methods of management of flail chest (1980)
    Springer
    Intensive care medicine 6 (1980), S. 217-221 
    Details
    ISSN: 1432-1238
    Keywords: Flail chest ; Pulmonary contusion ; IMV (Intermittent Mandatory Ventilation) ; PEEP (Positive End Expiratory Pressure)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have treated 30 patients with flail chest, with priority given to associated factors (pain, secretions retention, hemo-/pneumothorax and underlying pulmonary contusion). When this treatment was insufficient IMV+PEEP was instituted; in this group there was a 58.8% incidence of pneumonia, 47.5% of sepsis and 11.7 days average stay in the ICU. These were significantly different when compared to the patients controlled without mechanical ventilatory support (7.7% pneumonia, 0% sepsis, 3.2 days). Surgical fixation was limited to 4 patients who presented with multiple and greatly displaced rib fractures, which made fixation by mechanical ventilation unpredictable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01687161
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Oxidative polymorphism of debrisoquine is not related to human colo-rectal cancer (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 525-527 
    Details
    ISSN: 1432-1041
    Keywords: Colon cancer ; polymorphism ; debrisoquine ; rectal cancer ; cytochrome P 450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The oxidative polymorphism of debrisoquine (DBQ) has been determined in 89 patients with colo-rectal cancer and in 556 normal control subjects. Four patients and 34 controls, with a metabolic ratio 〉12.6, were classified as poor metabolisers of DBQ (n.s.). No difference was found in the distribution of the frequencies of the MR of DBQ between patients and controls. It is concluded that polymorphic oxidation of DBQ is not related to the risk of developing colo-rectal cancer in human beings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315234
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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