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  • 1
    Electronic Resource
    Electronic Resource
    Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 165 (1989), S. 554-560 
    Details
    ISSN: 0006-291X
    Keywords: [abr] CTX; cholera toxin ; [abr] DADLE; [D-Ala^2,D-Leu^5]enkephalin ; [abr] G"i; inhibitory G-protein ; [abr] G"o; G-protein abundant in brain tissue ; [abr] G"s; stimulatory G-protein ; [abr] G-protein; guanine nucleotide binding regulatory protein ; [abr] ICI 174864; [N,N'-diallyl-Tyr^1,Aib^2^,^3]Leu-enkephalin ; [abr] NLX; naloxone ; [abr] SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel ; [abr] kDa; kilodalton
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(89)80002-6
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 165 (1989), S. 554-560 
    Details
    ISSN: 0006-291X
    Keywords: [abr] CTX; cholera toxin ; [abr] DADLE; [D-Ala^2,D-Leu^5]enkephalin ; [abr] G"i; inhibitory G-protein ; [abr] G"o; G-protein abundant in brain tissue ; [abr] G"s; stimulatory G-protein ; [abr] G-protein; guanine nucleotide binding regulatory protein ; [abr] ICI 174864; [N,N'-diallyl-Tyr^1,Aib^2^,^3]Leu-enkephalin ; [abr] NLX; naloxone ; [abr] SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel ; [abr] kDa; kilodalton
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(89)80002-6
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Direct modulation of voltage-dependent calcium channels by muscarinic activation of a pertussis toxin-sensitive G-protein in hippocampal neurons (1989)
    Springer
    Pflügers Archiv 415 (1989), S. 255-261 
    Details
    ISSN: 1432-2013
    Keywords: Ca channels ; G-proteins ; Hippocampus ; Acetylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acetylcholine (Ach) reversibly reduces the high voltage-activated (HVA) calcium (Ca) current in hippocampal neurons. Pretreatment of the cells with pertussis toxin (PTX) abolishes the Ach effect, suggesting that PTX-sensitive GTP-binding regulatory proteins (G-proteins) are involved in the signal transduction mechanism that links Ach receptor activation to inhibition of Ca channel activity. This effect is mimicked by intracellular application of the nonhydrolyzable GTP analog GTPγS. Intracellular application of purified G-proteins restored the response to Ach in PTX-treated cells. Furthermore, Ach inhibits the Ca current independently of the presence of cyclic AMP and of the protein kinase C inhibitor H-7 and neither does the Ach effect on the Ca current seem to be correlated to a transient increase in intracellular Ca. Our results suggest that activation of the α-subunit of the PTX-sensitive G-protein could directly modulate the HVA Ca channel without involving second messenger systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370874
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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