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  • 1
    Electronic Resource
    Electronic Resource
    Conditioned modifications of arousal and unit activity in the rat hippocampus (1980)
    Springer
    Experimental brain research 38 (1980), S. 95-101 
    Details
    ISSN: 1432-1106
    Keywords: Hippocampus ; Unit activity ; Conditioned modifications of arousal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two main types of neurons were recorded in the dorsal hippocampus of chronic rats. Type I neurons were characterized by a bursting mode of discharge. Their activity was higher during slow wave sleep (SWS) than during wakefulness (W) or paradoxical sleep (PS). They had an “inhibitory” response (decrease in spike frequency) to desynchronizing stimuli presented during a SWS episode. Type II neurons had a mean spike frequency greater than 10/s. Some of them, (group IIa), were more active during W and PS than during SWS and had an “excitatory” response (increase in spike frequency) to desynchronizing stimuli. Activity of other type II neurons, group IIb, had no relationship with the arousal level. An arousal response (neocortical EEG desynchrony) was classically conditioned to an acoustical CS. During that conditioning, most of the type I neurons rapidly displayed an inhibitory conditioned response (CR). This unit response was closely associated with the EEG CR. The majority of the type II neurons did not demonstrate signs of conditioning (group IIb). The others, group IIa, gradually developed an excitatory CR at moderate levels. This unit CR seemed to be independent of conditioned modifications of arousal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237935
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656 (1992)
    Springer
    Psychopharmacology 107 (1992), S. 415-424 
    Details
    ISSN: 1432-2072
    Keywords: Roman strains ; Psychogenetic selection ; Working memory ; Exploratory behaviour ; Spontaneous alternation ; Radial maze ; Object recognition ; Acetylcholine ; Dopamine ; Noradrenaline ; Serotonin ; Hippocampus ; Frontal cortex ; Striatum ; RU 41656 ; D2 agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the effects of RU 41656, a dopaminergic D2 agonist, on the differential working memory performances and on the differential activities of the neurochemical systems of the Roman high (RHA) and Roman low (RLA) avoidance strains of rats. Compared with RLA, RHA performed worse in three tests of working memory (spontaneous alternation, radial maze and object recognition) and had higher levels of exploratory locomotor activity. Hippocampal and frontal cortex choline acetyltransferase (ChAT) activities were loer in RHA. Frontal cortex DA and DOPAC levels, hippocampal and striatal 5-HT and NA levels were higher in RHA. RU 41656 induced a significant improvement in working memory performance of RHA, whereas in RLA it had no effect. It decreased exploratory locomotor activity in both strains. ChAT activity in hippocampus was not affected by RU 41656 in either strain, whereas in frontal cortex it was increased in RHA but not in RLA. Hippocampal NA levels were decreased by RU 41656 in RHA but not in RLA. These results confirm previous data concerning the promnesic effect of RU 41656 and extend the finding that the Roman strains are a psychogenetic model for the behavioural, neurochemical and psychopharmacological study of the working memory in rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245169
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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