ISSN:
1432-0533
Keywords:
Acquired immune deficiency syndrome (AIDS)
;
Human immune deficiency virus (HIV)
;
Cerebral toxoplasmosis
;
Progressive multifocal leucoencephalopathy
;
Papovavirus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 29-year-old homosexual male with AIDS presented with progressive encephalopathy and cytomegalovirus (CMV) pneumonia. Neuropathological examination revealed toxoplasma abcesses in corpus callosum, basal ganglia and cerebellar white matter; demyelinating foci in the parietal white matter, with microscopic changes typical of progressive multifocal leucoencephalopathy and intranuclear papovavirus inclusions in oligodendrocytes; and lesions of subacute encephalitis in the periventricular regions with large cells positive by immunostaining for CMV. Diffuse myelin loss was observed in the cerebral white matter. Multinucleated giant cells were numerous in the demyelinated areas, they were also observed in close relationship with papova, CMV and Toxoplasma lesions. Immunostaining of these cells was positive for histiocyte markers and negative with the leucocyte common antigen monoclonal antibody. Some of them contained virus-like particles measuring around 100 nm similar to human immune deficiency virus (HIV) as observed in human brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00695508
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