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  • Acrobic capacity  (1)
  • angiotensin antagonist  (1)
  • beta-blockers  (1)
  • 1
    ISSN: 1432-1076
    Keywords: Exercise testing ; Congenital heart disease ; Acrobic capacity ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aerobic capacity of patients with different forms of congenital heart disease was serially evaluated in 79 patients and the evolution was correlated with the lesion and the level of daily activity. The patients were divided into six groups: patients with a small ventricular septal defect (VSD) with mini shunt (n=14), mild pulmonary valve stenosis with gradient 〈40 mm Hg (PS) (n=12), mild to moderate aortic valve stenosis (gradient 36±17 mm Hg) (AS) (n=12), patients 4.7±2.1 years after repair of tetralogy of Fallot (PO-TF) (n=16), patients 2.2±2.9 years after closure of a high flow/high gradient VSD (PO-VSD) (n=13), and patients 2.6±1.7 years after Fontan repair (Fontan-PO) (n=12). Aerobic capacity was assessed by determination of the ventilatory anaerobic threshold (VAT). VAT reflects the highest aerobic exercise level prior to a disproportionate increase of CO2 and ventilation relative to O2 uptake; it is independent of patient motivation. Data are expressed as percentage of normal O2 uptake at VAT, determined in 234 age/gender matched controls. The habitual level of physical activity was assessed by a standardised questionnaire. Aerobic capacity in all subgroups of patients, even with very mild defects, was at or below the lower limit of normal. Children left unrestricted from physical exercise (VSD, PS, PO-VSD) had no change over the study period. However, aerobic capacity of patients with medically imposed physical restrictions (AS) and significant residual haemodynamic lesions (PO-TF, Fontan) decreased with age. In patients with AS, PO-TF and Fontan-PO the habitual level of physical activity was significantly decreased compared to controls. Conclusion Cardiovascular exercise performance in children with medically imposed restriction of intensive physical exercise (AS) or residual haemodynamic lesions (TF and Fontan-PO) declines progressively during medium-term follow up. In the other patient groups (VSD, PS, VSD-PO), exercise performance remains stable.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 10 (1976), S. 297-303 
    ISSN: 1432-1041
    Keywords: Hypertension ; beta-blockers ; atenolol ; propranolol ; isoprenaline-tachycardia ; exercise tachycardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The comparative potency of two beta-blockers, propranolol and atenolol, in the inhibition of exercise tachycardia and isoproterenol-tachycardia has been studied in two groups of hypertensive patients, using oral doses which were increased weekly. A linear correlation was observed between the reduction in exercise tachycardia and the dose of each drug, up to a daily dose of propranolol 480 mg and atenolol 600 mg. Propranolol was slightly (0.7/1) more potent in decreasing maximal exercise tachycardia than atenolol when tested in low doses (below 100 mg); at higher doses (480 mg) no differences were found. However, atenolol was 10 times less potent than propranolol in blocking isoprenaline-induced tachycardia, which seems to be related to the cardioselectivity of atenolol.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Hypertension ; low sodium diet ; angiotensin antagonist ; plasma renin ; chlorthalidone ; hypotensive effect ; sodium depletion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypotensive effect of acute sodium volume depletion, produced by chlorthalidone and a low sodium diet, was inversely related to the plasma renin concentration (PRC) in 13 hypertensive patients of varying aetiology (r=0.61; p〈0.05); weight reduction induced by this therapy was not related to PRC (r=0.12; p〉0.1). The angiotensin II antagonist 1-sar-8-ala-angiotensin II failed to reduce arterial pressure when the patients ingested 130 mEq sodium per day, but pressure fell when it was infused during sodium volume depletion, except when PRC remained low; the changes in pressure were related to the plasma renin level (r=0.78; p〈0.005). The combined hypotensive response to acute sodium volume depletion and to angiotensin II blockade during sodium volume depletion was not related to PRC (r=0.15; p〉0.1). The results demonstrate that acute sodium volume depletion caused similar weight loss in patients with high and low PRC values, and it would have had similar hypotensive effects but for angiotensin-induced vasoconstriction in the high renin patients. Since 1-sar-8-ala-angiotensin II also reduced arterial pressure in 6 patients during chronic diuretic therapy, angiotensin II must still induce vasoconstriction in these circumstances.
    Type of Medium: Electronic Resource
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