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Digitale Medien

Neuropathological alterations in the neocortex of rats subjected to focal aminopyridine seizures (1983)

Mihály, A. ; Joo, F. ; Szente, M.

Springer

Acta neuropathologica 61 (1983), S. 85-94

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Details

ISSN: 1432-0533

Schlagwort(e): Acute seizure ; Neuronal shrinkage ; Dendritic swelling ; Synapses ; Aminopyridines

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Acute focal seizures were produced in anaesthetized albino rats by topical application of 3- and 4-aminopyridine on the exposed fronto-parietal neocortical areas. After 15 min of seizure activity neuronal and glial changes were studied by light (toluidine blue and Golgi staining) and electron microscopy. Shrinkage and increased electron density of some pyramidal cells, astrocytic swelling and depletion of 40–60 nm synaptic vesicles from the nerve terminals in layers I, II and III were found. The possible significance of the alterations in the seizure is discussed.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00697386

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